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In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity.
Le Barz, Mélanie; Daniel, Noëmie; Varin, Thibault V; Naimi, Sabrine; Demers-Mathieu, Véronique; Pilon, Geneviève; Audy, Julie; Laurin, Émilie; Roy, Denis; Urdaci, Maria C; St-Gelais, Daniel; Fliss, Ismaïl; Marette, André.
Afiliación
  • Le Barz M; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute Research Centre, Laval University, Québec, Canada.
  • Daniel N; Institute of Nutrition and Functional Foods, Laval University, Québec, Canada.
  • Varin TV; Unité Mixte de Recherche 5248, Laboratory of Microbiology and Applied Biochemistry, University of Bordeaux, Gradignan, France.
  • Naimi S; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute Research Centre, Laval University, Québec, Canada.
  • Demers-Mathieu V; Institute of Nutrition and Functional Foods, Laval University, Québec, Canada.
  • Pilon G; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute Research Centre, Laval University, Québec, Canada.
  • Audy J; Institute of Nutrition and Functional Foods, Laval University, Québec, Canada.
  • Laurin É; Institute of Nutrition and Functional Foods, Laval University, Québec, Canada.
  • Roy D; Dairy Science and Technology Research Centre, Laval University, Quebec, Canada.
  • Urdaci MC; Institute of Nutrition and Functional Foods, Laval University, Québec, Canada.
  • St-Gelais D; Dairy Science and Technology Research Centre, Laval University, Quebec, Canada.
  • Fliss I; Saint-Hyacinthe Research and Development Centre, Agriculture and Agri-Food Canada, Saint-Hyacinthe, Canada.
  • Marette A; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute Research Centre, Laval University, Québec, Canada.
FASEB J ; 33(4): 4921-4935, 2019 04.
Article en En | MEDLINE | ID: mdl-30596521
Given the growing evidence that gut dysfunction, including changes in gut microbiota composition, plays a critical role in the development of inflammation and metabolic diseases, the identification of novel probiotic bacteria with immunometabolic properties has recently attracted more attention. Herein, bacterial strains were first isolated from dairy products and human feces and then screened in vitro for their immunomodulatory activity. Five selected strains were further analyzed in vivo, using a mouse model of diet-induced obesity. C57BL/6 mice were fed a high-fat high-sucrose diet, in combination with 1 of 3 Lactobacillus strains (Lb38, L. plantarum; L79, L. paracasei/casei; Lb102, L. rhamnosus) or Bifidobacterium strains (Bf26, Bf141, 2 different strains of B. animalis ssp. lactis species) administered for 8 wk at 109 colony-forming units/d. Whereas 3 strains showed only modest (Lb38, Bf26) or no (L79) effects, Lb102 and Bf141 reduced diet-induced obesity, visceral fat accretion, and inflammation, concomitant with improvement of glucose tolerance and insulin sensitivity. Further analysis revealed that Lb102 and Bf141 enhanced intestinal integrity markers in association with selective changes in gut microbiota composition. We have thus identified 2 new potential probiotic bacterial strains with immunometabolic properties to alleviate obesity development and associated metabolic disturbances.-Le Barz, M., Daniel, N., Varin, T. V., Naimi, S., Demers-Mathieu, V., Pilon, G., Audy, J., Laurin, E., Roy, D., Urdaci, M. C., St-Gelais, D., Fliss, I, Marette, A. In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Lacticaseibacillus rhamnosus / Bifidobacterium animalis / Obesidad Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Lacticaseibacillus rhamnosus / Bifidobacterium animalis / Obesidad Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos