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An Increased Neutrophil-to-Lymphocyte Ratio Predicts Incomplete Response to Therapy in Differentiated Thyroid Cancer.
Lee, Fang; Yang, Po-Sheng; Chien, Ming-Nan; Lee, Jie-Jen; Leung, Ching-Hsiang; Cheng, Shih-Ping.
Afiliación
  • Lee F; Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
  • Yang PS; Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
  • Chien MN; Division of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
  • Lee JJ; Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
  • Leung CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
  • Cheng SP; Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
Int J Med Sci ; 15(14): 1757-1763, 2018.
Article en En | MEDLINE | ID: mdl-30588200
Background: Previously we have shown that an elevated baseline neutrophil-to-lymphocyte ratio (NLR) was associated with a high risk of recurrence in patients with differentiated thyroid cancer. The clinical significance of the longitudinal changes in NLR following treatment remained unestablished. Methods: Adults patients with differentiated thyroid cancer were included in the study if the follow-up NLR data at 6 to 18 months after initial treatment were available. The response to treatment was categorized as excellent, indeterminate, biochemical incomplete, and structural incomplete as per guidelines of the American Thyroid Association. Results: Among 151 patients with thyroid cancer, a significant decrease in NLR following treatment was observed in those with stage I disease, those with low risk of recurrence, and those with an excellent response to therapy. Patients with a structural incomplete response had a significant increase in NLR at follow-up (p = 0.012). On multivariate analysis, incomplete response to therapy was associated with male sex (odds ratio [OR] = 3.35), tumor size (OR = 1.63), lymph node metastasis (OR = 4.80), distant metastasis (OR = 12.95), and increased NLR (OR = 13.68). Conclusions: An increase in systemic inflammation following treatment as measured by NLR is independently associated with an incomplete response to therapy in differentiated thyroid cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Linfocitos / Biomarcadores de Tumor / Recurrencia Local de Neoplasia / Neutrófilos Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Linfocitos / Biomarcadores de Tumor / Recurrencia Local de Neoplasia / Neutrófilos Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Australia