Revisiting inflammation in bipolar disorder.

Fries, Gabriel R; Walss-Bass, Consuelo; Bauer, Moises E; Teixeira, Antonio L

Fries, Gabriel R; Walss-Bass, Consuelo; Bauer, Moises E; Teixeira, Antonio L.

Afiliación

Fries GR; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77054 East Rd., Houston, TX, United States of America.
Walss-Bass C; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77054 East Rd., Houston, TX, United States of America.
Bauer ME; School of Sciences, PUCRS, Brazil.
Teixeira AL; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77054 East Rd., Houston, TX, United States of America. Electronic address: Antonio.L.Teixeira@uth.tmc.edu.

Pharmacol Biochem Behav ; 177: 12-19, 2019 02.

Article en En | MEDLINE | ID: mdl-30586559

RESUMEN

Bipolar disorder (BD) has been associated with immune changes, and yet their underlying mechanisms are still not fully understood. Here, we review the current state of the field, concerning the inflammatory alterations observed in the periphery and in the central nervous system, followed by a discussion of potential underlying mechanisms. We focus mainly on recently proposed mechanisms including the role of the gut-brain axis, the release of damage-associated molecular patterns (DAMPs), and the genetic and epigenetic mechanisms. BD immunology is an evolving field and current studies indicate this disease is more than a brain disorder, and it can be conceptualized as a multi-system condition.

Asunto(s)

Trastorno Bipolar/inmunología; Trastorno Bipolar/fisiopatología; Inflamación/inmunología; Alarminas/metabolismo; Antiinflamatorios/uso terapéutico; Trastorno Bipolar/tratamiento farmacológico; Encéfalo/metabolismo; Citocinas/metabolismo; Epigénesis Genética/genética; Microbioma Gastrointestinal/inmunología; Humanos; Sistema Hipotálamo-Hipofisario/metabolismo; Microglía/metabolismo

Palabras clave

Bipolar disorder; Comorbidity; Cytokines; Immune system; Inflammation; Microbiota

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Inflamación Límite: Humans Idioma: En Revista: Pharmacol Biochem Behav Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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