[Screening of nucleic acid aptamer of lung cancer cells based on cell exponential enrichment ligand system evolution and its application in tumor diagnosis and treatment].

Xu, Jinling; Liao, Shiqi; Tian, Caiping; Zhang, Lei; Zhai, Meng; Chen, Congying; Tang, Jinzhou; Zeng, Jiayu

Xu, Jinling; Liao, Shiqi; Tian, Caiping; Zhang, Lei; Zhai, Meng; Chen, Congying; Tang, Jinzhou; Zeng, Jiayu.

Afiliación

Xu J; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Liao S; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Tian C; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Zhang L; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Zhai M; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Chen C; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Tang J; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Zeng J; Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 35(6): 964-969, 2018 12 25.

Article en Zh | MEDLINE | ID: mdl-30583324

RESUMEN

Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.

Palabras clave

aptamer; lung cancer cells; systematic evolution of ligands for cell exponential enrichment technology; tumor diagnosis and treatment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: Zh Revista: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article Pais de publicación: China

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