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Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy.
Perez-Riverol, Amilcar; Lasa, Alexis Musacchio; Dos Santos-Pinto, José Roberto Aparecido; Palma, Mario Sergio.
Afiliación
  • Perez-Riverol A; Center of the Study of Social Insects, Department of Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNESP), Rio Claro, SP, 13500, Brazil.
  • Lasa AM; Center for Genetic Engineering and Biotechnology, Biomedical Research Division, Department of System Biology, Ave. 31, e/158 and 190, P.O. Box 6162, Cubanacan, Playa, Havana, 10600, Cuba.
  • Dos Santos-Pinto JRA; Center of the Study of Social Insects, Department of Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNESP), Rio Claro, SP, 13500, Brazil.
  • Palma MS; Center of the Study of Social Insects, Department of Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNESP), Rio Claro, SP, 13500, Brazil. Electronic address: mario.palma@unesp.br.
Insect Biochem Mol Biol ; 105: 10-24, 2019 02.
Article en En | MEDLINE | ID: mdl-30582958
Insect venom phospholipases have been identified in nearly all clinically relevant social Hymenoptera, including bees, wasps and ants. Among other biological roles, during the envenoming process these enzymes cause the disruption of cellular membranes and induce hypersensitive reactions, including life threatening anaphylaxis. While phospholipase A2 (PLA2) is a predominant component of bee venoms, phospholipase A1 (PLA1) is highly abundant in wasps and ants. The pronounced prevalence of IgE-mediated reactivity to these allergens in sensitized patients emphasizes their important role as major elicitors of Hymenoptera venom allergy (HVA). PLA1 and -A2 represent valuable marker allergens for differentiation of genuine sensitizations to bee and/or wasp venoms from cross-reactivity. Moreover, in massive attacks, insect venom phospholipases often cause several pathologies that can lead to fatalities. This review summarizes the available data related to structure, model of enzymatic activity and pathophysiological roles during envenoming process of insect venom phospholipases A1 and -A2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Artrópodos / Fosfolipasas A1 / Fosfolipasas A2 / Himenópteros / Mordeduras y Picaduras de Insectos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Insect Biochem Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Artrópodos / Fosfolipasas A1 / Fosfolipasas A2 / Himenópteros / Mordeduras y Picaduras de Insectos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Insect Biochem Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido