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Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity.
Korf, Hannelie; du Plessis, Johannie; van Pelt, Jos; De Groote, Sofie; Cassiman, David; Verbeke, Len; Ghesquière, Bart; Fendt, Sarah-Maria; Bird, Matthew J; Talebi, Ali; Van Haele, Matthias; Feio-Azevedo, Rita; Meelberghs, Lore; Roskams, Tania; Mookerjee, Rajeshwar P; Mehta, Gautam; Jalan, Rajiv; Gustot, Thierry; Laleman, Wim; Nevens, Frederik; van der Merwe, Schalk Willem.
Afiliación
  • Korf H; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • du Plessis J; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • van Pelt J; Department of Immunology, University of Pretoria, Pretoria, South Africa.
  • De Groote S; Department of Oncology, KU Leuven, and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Cassiman D; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Verbeke L; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Ghesquière B; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium.
  • Fendt SM; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Bird MJ; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium.
  • Talebi A; Metabolomics Expertise Centrum, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium.
  • Van Haele M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium.
  • Feio-Azevedo R; Department of Oncology, Laboratory of Cellular Metabolism and Metabolic Regulation, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Meelberghs L; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Roskams T; Metabolomics Expertise Centrum, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium.
  • Mookerjee RP; Department of Oncology, Laboratory of Lipid Metabolism and Cancer, KU Leuven and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.
  • Mehta G; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
  • Jalan R; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Gustot T; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • Laleman W; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
  • Nevens F; Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK.
  • van der Merwe SW; Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK.
Gut ; 68(10): 1872-1883, 2019 10.
Article en En | MEDLINE | ID: mdl-30580251
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Monocitos / Insuficiencia Hepática Crónica Agudizada / Glutamato-Amoníaco Ligasa / Inmunosupresores Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 2019 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Monocitos / Insuficiencia Hepática Crónica Agudizada / Glutamato-Amoníaco Ligasa / Inmunosupresores Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 2019 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido