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Twenty years of growth hormone treatment in dialyzed children in Poland-Results of national multicenter study.
Adamczuk, Dominika; Leszczynska, Beata; Skrzypczyk, Piotr; Turczyn, Agnieszka; Antonowicz, Agnieszka; Majcher, Anna; Szczepanska, Maria; Adamczyk, Piotr; Zagozdzon, Ilona; Zurowska, Aleksandra; Tkaczyk, Marcin; Jander, Anna; Sikora, Przemyslaw; Wasilewska, Anna; Warzywoda, Alfred; Kilis-Pstrusinska, Katarzyna; Zwolinska, Danuta; Zachwieja, Katarzyna; Drozdz, Dorota; Stankiewicz, Roman; Grenda, Ryszard; Panczyk-Tomaszewska, Malgorzata.
Afiliación
  • Adamczuk D; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
  • Leszczynska B; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
  • Skrzypczyk P; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. Electronic address: pskrzypczyk@wum.edu.pl.
  • Turczyn A; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
  • Antonowicz A; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
  • Majcher A; Department of Pediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
  • Szczepanska M; Dialysis Division for Children, Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
  • Adamczyk P; Dialysis Division for Children, Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
  • Zagozdzon I; Department Pediatrics, Nephrology & Hypertension, Medical University of Gdansk, Poland.
  • Zurowska A; Department Pediatrics, Nephrology & Hypertension, Medical University of Gdansk, Poland.
  • Tkaczyk M; Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lódz, Poland.
  • Jander A; Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lódz, Poland.
  • Sikora P; Department of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland.
  • Wasilewska A; Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland.
  • Warzywoda A; Department of Pediatric Cardiology and Nephrology, Poznan University of Medical Sciences, Poznan, Poland.
  • Kilis-Pstrusinska K; Department of Paediatric Nephrology, Wroclaw Medical University, Poland.
  • Zwolinska D; Department of Paediatric Nephrology, Wroclaw Medical University, Poland.
  • Zachwieja K; Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Kraków, Poland.
  • Drozdz D; Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Kraków, Poland.
  • Stankiewicz R; Department of Pediatric Nephrology, Specialist Municipal Hospital, Torun, Poland.
  • Grenda R; Department of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
  • Panczyk-Tomaszewska M; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Adv Med Sci ; 64(1): 90-99, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30580206
PURPOSE: The aim of the study was to analyze the effect of recombinant human growth hormone (rhGH) therapy and to establish factors influencing growth rate in dialyzed children in Poland. METHODS: We retrospectively analyzed medical records of 81 children with end-stage renal disease (ESRD) on chronic dialysis treated with rhGH for ≥12 months between 1994 and 2014. The following data were recorded: cause of ESRD, dialysis modality, age at the dialysis and rhGH initiation [years]. In addition, growth [cm], [standard deviation score - SDS], body mass index [SDS], skeletal age [years], bone mineral density [SDS], hemoglobin, total protein, albumin, urea, creatinine, calcium, phosphorus, calcium phosphorus product, PTH, and alkaline phosphatase were measured at the baseline and after 12 months. RESULTS: Growth velocity in 81 children during one-year rhGH treatment was 7.33 ± 2.63 cm (ΔSDS 0.36 ± 0.43). Height SDS increased significantly (-3.31 ± 1.12 vs. -2.94 ± 1.15, p < 0.001). Children on peritoneal dialysis (PD) (n = 51) were younger than children on hemodialysis (HD) (n = 30) (9.92 ± 3.72 vs. 12.32 ± 3.11 years, p = 0.003). ΔSDS did not differ between PD and HD children (0.40 ± 0.33 vs. 0.30 ± 0.47, p = 0.311). Growth velocity (ΔSDS) correlated with age at dialysis initiation (r=-0.30, p = 0.009), age at rhGH treatment initiation (r=-0.35, p = 0.002), skeletal age (r=-0.36, p = 0.002), BMI SDS (r=-0.27, p = 0.019), and PTH (r=-0.27, p = 0.017). No correlation between growth velocity and other parameters was observed. CONCLUSIONS: Treatment with rhGH in children with ESRD is effective and safe irrespective of dialysis modality. Early initiation of rhGH therapy is a crucial factor determining response to the treatment in children with ESRD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Hormona de Crecimiento Humana Tipo de estudio: Clinical_trials Límite: Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Adv Med Sci Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Hormona de Crecimiento Humana Tipo de estudio: Clinical_trials Límite: Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Adv Med Sci Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos