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Thalamic shape and volume abnormalities in female patients with panic disorder.
Asami, Takeshi; Yoshida, Haruhisa; Takaishi, Masao; Nakamura, Ryota; Yoshimi, Asuka; Whitford, Thomas J; Hirayasu, Yoshio.
Afiliación
  • Asami T; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
  • Yoshida H; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
  • Takaishi M; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
  • Nakamura R; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
  • Yoshimi A; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
  • Whitford TJ; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
  • Hirayasu Y; Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
PLoS One ; 13(12): e0208152, 2018.
Article en En | MEDLINE | ID: mdl-30566534
The thalamus is believed to play crucial role in processing viscero-sensory information, and regulating the activity of amygdala in patients with panic disorder (PD). Previous functional neuroimaging studies have detected abnormal activation in the thalamus in patients with PD compared with healthy control subjects (HC). Very few studies, however, have investigated for volumetric abnormalities in the thalamus in patients with PD. Furthermore, to the best of our knowledge, no previous study has investigated for shape abnormalities in the thalamus in patients with PD. Twenty-five patients with PD and 25 HC participants (all female) were recruited for the study. A voxel-wise volume comparison analysis and a vertex-wise shape analysis were conducted to evaluate structural abnormalities in the PD patients compared to HC. The patients with PD demonstrated significant gray matter volume reductions in the thalamus bilaterally, relative to the HC. The shape analysis detected significant inward deformation in some thalamic regions in the PD patients, including the anterior nucleus, mediodorsal nucleus, and pulvinar nucleus. PD patients showed shape deformations in key thalamic regions that are believed to play a role in regulating emotional and cognitive functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno de Pánico / Núcleos Talámicos Anteriores / Pulvinar / Núcleo Talámico Mediodorsal Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno de Pánico / Núcleos Talámicos Anteriores / Pulvinar / Núcleo Talámico Mediodorsal Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos