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Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies.
Plummer, Erin A; Wang, Qi; Larson-Nath, Catherine M; Scheurer, Johannah M; Ramel, Sara E.
Afiliación
  • Plummer EA; Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States. Electronic address: plummer@umn.edu.
  • Wang Q; Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, United States.
  • Larson-Nath CM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
  • Scheurer JM; Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
  • Ramel SE; Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Early Hum Dev ; 129: 5-10, 2019 02.
Article en En | MEDLINE | ID: mdl-30562643
BACKGROUND: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. OBJECTIVE: To determine if body composition is associated with cognitive function in preschool-age children with CGIAs. STUDY DESIGN: An observational study examined body composition and cognition in 34 preschool-age children with CGIAs. Anthropometric measurements and body composition testing via air displacement plethysmography were obtained. Measurements were compared with a reference group of healthy, term-born children. Cognition was measured with the NIH Toolbox Early Childhood Cognition Battery. Linear regression was used to test the association of body composition with cognitive function. RESULTS: Compared with the reference group, children with CGIAs had similar anthropometric measurements (weight, height, and body mass index z-scores) and body composition at preschool-age. Processing speed scores were lower than standardized means (p = 0.001). Increased FFM was associated with higher receptive vocabulary scores (p = 0.001), cognitive flexibility scores (p = 0.005), and general cognitive function scores (p = 0.05). CONCLUSIONS: At preschool-age, children with CGIAs have similar growth and body composition to their peers. In children with CGIAs, higher FFM was associated with higher cognitive scores. Closer tracking of body composition and interventions aimed at increasing FFM may improve long-term outcomes in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Composición Corporal / Cognición / Anomalías del Sistema Digestivo Tipo de estudio: Observational_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Early Hum Dev Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Composición Corporal / Cognición / Anomalías del Sistema Digestivo Tipo de estudio: Observational_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Early Hum Dev Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda