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Use of MRI and FDG-PET/CT to predict fixation of advanced hypopharyngeal squamous cell carcinoma to prevertebral space.
Meerwein, Christian M; Pizzuto, Daniele A; Vital, Domenic; Morand, Grégoire B; Stolzmann, Paul; Huber, Gerhard F; Huellner, Martin W.
Afiliación
  • Meerwein CM; Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Pizzuto DA; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Zurich, Switzerland.
  • Vital D; Instituto di Medicina Nucleare, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Morand GB; Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Stolzmann P; Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Huber GF; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Zurich, Switzerland.
  • Huellner MW; Department of Otorhinolaryngology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Head Neck ; 41(2): 503-510, 2019 02.
Article en En | MEDLINE | ID: mdl-30561113
BACKGROUND: We evaluated the ability of different (18F)fluoro-deoxy-d-glucose (FDG)-positron emission tomography (PET)-based and magnetic resonance (MR)-based parameters to identify prevertebral space (PVS) infiltration by hypopharyngeal carcinoma. METHODS: Retrospective study on 59 patients with advanced hypopharyngeal squamous cell carcinoma undergoing cross-sectional imaging and triple endoscopy for staging. RESULTS: Obliteration of retropharyngeal fat plane on T1-weighted MR images was found more often (P < .001) in tumors fixated to the PVS. Complete fat plane obliteration best predicted tumor fixation to PVS (accuracy 99%; CI: 97%-100%; P < .001). With similar accuracy, PET-based models predicted PVS fixation (combination of standardized uptake value [SUVmax ] of the primary tumor and presence of focal FDG-uptake in prevertebral muscles [accuracy 98%; CI 94%-100%; P < .001]; metabolic tumor volume [MTV] [accuracy 98%; CI 95%-100%; P < .001]). CONCLUSION: Both the MR-based parameter of complete fat plane obliteration and PET-based models (increased SUVmax in combination with presence of focal FDG-uptake of prevertebral muscles; increased MTV) predict PVS involvement independently with high accuracy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Columna Vertebral / Imagen por Resonancia Magnética / Carcinoma de Células Escamosas / Neoplasias Hipofaríngeas / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Columna Vertebral / Imagen por Resonancia Magnética / Carcinoma de Células Escamosas / Neoplasias Hipofaríngeas / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos