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Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects.
Hufgard, Jillian R; Sprowles, Jenna L N; Pitzer, Emily M; Koch, Sheryl E; Jiang, Min; Wang, Qin; Zhang, Xiang; Biesiada, Jacek; Rubinstein, Jack; Puga, Alvaro; Williams, Michael T; Vorhees, Charles V.
Afiliación
  • Hufgard JR; Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.
  • Sprowles JLN; Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.
  • Pitzer EM; Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.
  • Koch SE; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Jiang M; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Wang Q; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Zhang X; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Biesiada J; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Rubinstein J; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Puga A; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
  • Williams MT; Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.
  • Vorhees CV; Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.
J Appl Toxicol ; 39(4): 603-621, 2019 04.
Article en En | MEDLINE | ID: mdl-30561030
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Reflejo de Sobresalto / Bifenilos Policlorados / Potenciación a Largo Plazo / Citocromo P-450 CYP1A2 / Contaminantes Ambientales / Fertilidad / Memoria Espacial Límite: Animals / Pregnancy Idioma: En Revista: J Appl Toxicol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Reflejo de Sobresalto / Bifenilos Policlorados / Potenciación a Largo Plazo / Citocromo P-450 CYP1A2 / Contaminantes Ambientales / Fertilidad / Memoria Espacial Límite: Animals / Pregnancy Idioma: En Revista: J Appl Toxicol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido