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Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota.
Kintses, Bálint; Méhi, Orsolya; Ari, Eszter; Számel, Mónika; Györkei, Ádám; Jangir, Pramod K; Nagy, István; Pál, Ferenc; Fekete, Gergely; Tengölics, Roland; Nyerges, Ákos; Likó, István; Bálint, Anita; Molnár, Tamás; Bálint, Balázs; Vásárhelyi, Bálint Márk; Bustamante, Misshelle; Papp, Balázs; Pál, Csaba.
Afiliación
  • Kintses B; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary. kintses.balint@brc.mta.hu.
  • Méhi O; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Ari E; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Számel M; Department of Genetics, Eötvös Loránd University, Budapest, Hungary.
  • Györkei Á; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Jangir PK; Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
  • Nagy I; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Pál F; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Fekete G; Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
  • Tengölics R; SeqOmics Biotechnology Ltd, Mórahalom, Hungary.
  • Nyerges Á; Sequencing Platform, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Likó I; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Bálint A; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Molnár T; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Bálint B; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
  • Vásárhelyi BM; Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
  • Bustamante M; Hereditary Endocrine Tumors Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
  • Papp B; 1st Department of Internal Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary.
  • Pál C; 1st Department of Internal Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary.
Nat Microbiol ; 4(3): 447-458, 2019 03.
Article en En | MEDLINE | ID: mdl-30559406
The human gut microbiota has adapted to the presence of antimicrobial peptides (AMPs), which are ancient components of immune defence. Despite its medical importance, it has remained unclear whether AMP resistance genes in the gut microbiome are available for genetic exchange between bacterial species. Here, we show that AMP resistance and antibiotic resistance genes differ in their mobilization patterns and functional compatibilities with new bacterial hosts. First, whereas AMP resistance genes are widespread in the gut microbiome, their rate of horizontal transfer is lower than that of antibiotic resistance genes. Second, gut microbiota culturing and functional metagenomics have revealed that AMP resistance genes originating from phylogenetically distant bacteria have only a limited potential to confer resistance in Escherichia coli, an intrinsically susceptible species. Taken together, functional compatibility with the new bacterial host emerges as a key factor limiting the genetic exchange of AMP resistance genes. Finally, our results suggest that AMPs induce highly specific changes in the composition of the human microbiota, with implications for disease risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacterias / Péptidos Catiónicos Antimicrobianos / Transferencia de Gen Horizontal / Microbioma Gastrointestinal / Genes Bacterianos Límite: Humans Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacterias / Péptidos Catiónicos Antimicrobianos / Transferencia de Gen Horizontal / Microbioma Gastrointestinal / Genes Bacterianos Límite: Humans Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido