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Effects of active and passive smoking on salivary cytokines levels in rats: A pilot study.
Ge, Sheng; Ye, Pei; Li, Guo-Yang; Fu, Yi-Fu; Zhou, Qian; Huang, Fan; Wang, Xiang; Wang, Wen-Mei.
Afiliación
  • Ge S; 1 Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Ye P; 2 Department of Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Li GY; 1 Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Fu YF; 3 Department of Clinical Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Zhou Q; 2 Department of Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Huang F; 1 Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Wang X; 1 Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
  • Wang WM; 1 Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Toxicol Ind Health ; 35(2): 109-118, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30558485
Cigarette smoking is an established risk factor for some oral diseases. As an essential fluid in the oral cavity, saliva is crucial to maintain oral health. Relative to active smoking, there are very few studies assessing the effect of passive smoking on salivary cytokines levels. In the present study, we established the rat models by the means of the intraoral cigarette smoking or whole body cigarette smoke exposure to simulate human active or passive smoking, respectively. The effects of active or passive smoking on salivary cytokines levels were assessed by using ProcartaPlex multiplex immunoassays. The results of the current study indicated that both active and passive smoking diminished the body weights of rats and increased the levels of some blood counts. Intriguingly, active smoking enhanced the salivary levels of IL-6 and IL-12 p70 and passive smoking elevated the salivary IL-6 level. Moreover, active smoking appeared to have a more prominent activation effect on the salivary IL-6 level. It was noted that active or passive smoking had no significant effect on the salivary IFN-γ level. Active or passive smoking could have potential effects on the salivary levels of some pro-inflammatory cytokines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Contaminación por Humo de Tabaco / Fumar / Citocinas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Contaminación por Humo de Tabaco / Fumar / Citocinas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido