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Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.
Sato, Kazuhide; Ando, Kanta; Okuyama, Shuhei; Moriguchi, Shiho; Ogura, Tairo; Totoki, Shinichiro; Hanaoka, Hirofumi; Nagaya, Tadanobu; Kokawa, Ryohei; Takakura, Hideo; Nishimura, Masayuki; Hasegawa, Yoshinori; Choyke, Peter L; Ogawa, Mikako; Kobayashi, Hisataka.
Afiliación
  • Sato K; Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, United States.
  • Ando K; Institute for Advanced Research, Nagoya University, Nagoya, Aichi 464-0814, Japan.
  • Okuyama S; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
  • Moriguchi S; Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan.
  • Ogura T; Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, United States.
  • Totoki S; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Hanaoka H; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Nagaya T; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Kokawa R; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Takakura H; Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, United States.
  • Nishimura M; Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, United States.
  • Hasegawa Y; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Choyke PL; Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan.
  • Ogawa M; Shimadzu Corporation, Kyoto 604-8511, Japan.
  • Kobayashi H; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
ACS Cent Sci ; 4(11): 1559-1569, 2018 Nov 28.
Article en En | MEDLINE | ID: mdl-30555909
Photochemical reactions can dramatically alter physical characteristics of reacted molecules. In this study, we demonstrate that near-infrared (NIR) light induces an axial ligand-releasing reaction, which dramatically alters hydrophilicity of a silicon phthalocyanine derivative (IR700) dye leading to a change in the shape of the conjugate and its propensity to aggregate in aqueous solution. This photochemical reaction is proposed as a major mechanism of cell death induced by NIR photoimmunotherapy (NIR-PIT), which was recently developed as a molecularly targeted cancer therapy. Once the antibody-IR700 conjugate is bound to its target, activation by NIR light causes physical changes in the shape of antibody antigen complexes that are thought to induce physical stress within the cellular membrane leading to increases in transmembrane water flow that eventually lead to cell bursting and necrotic cell death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Cent Sci Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Cent Sci Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos