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VEGF-A Links Angiolymphoid Hyperplasia With Eosinophilia (ALHE) to THSD7A Membranous Nephropathy: A Report of 2 Cases.
Matsumoto, Ayumi; Matsui, Isao; Namba, Tomoko; Sakaguchi, Yusuke; Mizuno, Hitoshi; Shirayama, Yuki; Shimada, Karin; Hashimoto, Nobuhiro; Doi, Yohei; Yamaguchi, Satoshi; Kubota, Keiichi; Oka, Tatsufumi; Mori, Daisuke; Akiyama, Shinichi; Hamano, Takayuki; Mizui, Masayuki; Takabatake, Yoshitsugu; Kaneko, Tetsuya; Isaka, Yoshitaka.
Afiliación
  • Matsumoto A; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Matsui I; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: matsui@kid.med.osaka-u.ac.jp.
  • Namba T; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Sakaguchi Y; Department of Inter-Organ Communication Research in Kidney Disease, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Mizuno H; Department of Nephrology, NTT Osaka Hospital, Osaka, Japan.
  • Shirayama Y; Department of Nephrology, NTT Osaka Hospital, Osaka, Japan.
  • Shimada K; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Hashimoto N; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Doi Y; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Yamaguchi S; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Kubota K; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Oka T; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Mori D; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Akiyama S; Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
  • Hamano T; Department of Inter-Organ Communication Research in Kidney Disease, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Mizui M; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Takabatake Y; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Kaneko T; Department of Nephrology, NTT Osaka Hospital, Osaka, Japan.
  • Isaka Y; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
Am J Kidney Dis ; 73(6): 880-885, 2019 06.
Article en En | MEDLINE | ID: mdl-30554801
Autoantibodies against thrombospondin type 1 domain-containing 7A (THSD7A) cause membranous nephropathy (MN); however, the mechanisms involved in THSD7A expression and immunization are uncertain. We present 2 cases of THSD7A-associated MN accompanied by angiolymphoid hyperplasia with eosinophilia (ALHE), a benign tumor characterized by proliferation of plump endothelial cells. Prednisolone therapy, but not surgical resection of ALHE tumors, successfully suppressed eosinophilia and proteinuria in both cases. Because ALHE is characterized by the proliferation of plump endothelial cells, we focused on the roles of vascular endothelial growth factor A (VEGF-A) in MN pathogenesis. We found that plump endothelial cells in ALHE modestly expressed THSD7A in both cases. We also found that eosinophils in ALHE expressed VEGF-A, which upregulated THSD7A expression, especially under T-helper type 2-prone conditions in cultured endothelial cells. Furthermore, double-positive cells for THSD7A and CD83 surrounded the proliferated small vessels. Our results suggest that VEGF-A-induced THSD7A expression outside the kidney may be important for MN pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prednisolona / Glomerulonefritis Membranosa / Trombospondinas / Factor A de Crecimiento Endotelial Vascular / Hiperplasia Angiolinfoide con Eosinofilia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Kidney Dis Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prednisolona / Glomerulonefritis Membranosa / Trombospondinas / Factor A de Crecimiento Endotelial Vascular / Hiperplasia Angiolinfoide con Eosinofilia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Kidney Dis Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos