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Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.
Dua, Kamal; Malyla, Vamshikrishna; Singhvi, Gautam; Wadhwa, Ridhima; Krishna, Rapalli Vamshi; Shukla, Shakti Dhar; Shastri, Madhur D; Chellappan, Dinesh Kumar; Maurya, Pawan Kumar; Satija, Saurabh; Mehta, Meenu; Gulati, Monica; Hansbro, Nicole; Collet, Trudi; Awasthi, Rajendra; Gupta, Gaurav; Hsu, Alan; Hansbro, Philip M.
Afiliación
  • Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Aust
  • Malyla V; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia.
  • Singhvi G; Department of Pharmacy, Birla Institute of Technology and Science (BITS), Pilani, 333031, India.
  • Wadhwa R; Faculty of Life Sciences and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi, 110021, India.
  • Krishna RV; Department of Pharmacy, Birla Institute of Technology and Science (BITS), Pilani, 333031, India.
  • Shukla SD; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia.
  • Shastri MD; School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.
  • Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia.
  • Maurya PK; Department of Biochemistry, Central University of Haryana, Jant-Pali, Mahendergarh District, 123031, Haryana, India.
  • Satija S; School of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, Punjab, 144441, India.
  • Mehta M; School of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, Punjab, 144441, India.
  • Gulati M; School of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, Punjab, 144441, India.
  • Hansbro N; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia; Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Centre for Inflammation,
  • Collet T; Indigenous Medicines Group, Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, 4059, Australia.
  • Awasthi R; Amity Institute of Pharmacy, Amity University, Sec. 125, Noida, 201303, Uttar Pradesh, India.
  • Gupta G; School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India.
  • Hsu A; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia.
  • Hansbro PM; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia; Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Centre for Inflammation,
Chem Biol Interact ; 299: 168-178, 2019 Feb 01.
Article en En | MEDLINE | ID: mdl-30553721
Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Enfermedades Pulmonares Obstructivas Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Chem Biol Interact Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Enfermedades Pulmonares Obstructivas Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Chem Biol Interact Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda