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The feasibility and efficacy of subcutaneous plerixafor for mobilization of peripheral blood stem cells in allogeneic HLA-identical sibling donors: results of the HOVON-107 study.
de Greef, Georgine E; Braakman, Eric; van der Holt, Bronno; Janssen, Jeroen J W M; Petersen, Eefke; Vucinic, Vladimir; Thuss, Nicole; Grootes, Meriam; Cornelissen, Jan J.
Afiliación
  • de Greef GE; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
  • Braakman E; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
  • van der Holt B; Department of Hematology, HOVON Data Center. Erasmus MC, Rotterdam, Netherlands.
  • Janssen JJWM; Department of Hematology, VU University Hospital, Amsterdam, Netherlands.
  • Petersen E; Department of Hematology, UMC Utrecht, Utrecht, Netherlands.
  • Vucinic V; Department of Hematology, Clinical Oncology and Hemostaseology, University of Leipzig, Leipzig, Germany.
  • Thuss N; Department of Hematology, HOVON Data Center. Erasmus MC, Rotterdam, Netherlands.
  • Grootes M; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
  • Cornelissen JJ; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Transfusion ; 59(1): 316-324, 2019 01.
Article en En | MEDLINE | ID: mdl-30548284
BACKGROUND: Plerixafor (PFX) mobilizes CD34+ cells into circulation by disrupting the CXCR4 binding of the hematopoietic stem cell in its bone marrow niche. STUDY DESIGN AND METHODS: in the prospective HOVON-107 study (www.hovon.nl) 23 allogeneic HLA-identical sibling donors received one or two subcutaneous (sc) injections of plerixafor 0.320 mg/kg.The primary endpoint, was defined as feasibility to mobilize a minimum of 2.0 x106 CD34+ cells/kg recipient weight obtained by leukopheresis in at least 90% of the donors. RESULTS: median 3.3 x 106 CD34+ cells/kg (1.9-6.5) were collected after 1 (n=12) or 2 (n=10) sc injections of PFX. Side effects occurred in 15/23 (65%) donors: most were grade 1-2; in 5 donors grade 3 and all resolved. All grafts were directly transplanted. Compared to 10 grafts obtained with G-CSF the number of CD34+ cells was 2.4 fold lower but the percentage of phenotypically most immature CD34+ subset was higher (31% vs 15%). The total number of CD3+ cells in the graft seemed higher after PFX-mobilization, but CD4/CD 8 ratios, and frequencies of Th2, Th17 and regulatory T-cells or NK cells were comparable. All patients engrafted and no increase in incidence or severity of acute or chronic graft versus host disease was observed. CONCLUSION: stem cell mobilization with sc PFX 0.320 mg/kg in allogeneic sibling donors is feasible with limited toxicity for donors. 14 allogeneic donors were mobilized with PFX 0.320 mg intravenously according to the same protocol. Due to the limited numbers, these results are in the supplementary section.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre de Sangre Periférica / Compuestos Heterocíclicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transfusion Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre de Sangre Periférica / Compuestos Heterocíclicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transfusion Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos