A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at ambient temperature.

Kardooni, Rezvan; Kiasat, Ali Reza

Kardooni, Rezvan; Kiasat, Ali Reza.

Afiliación

Kardooni R; Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran. rezvankardooni@ymail.com.
Kiasat AR; Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. rezvankardooni@ymail.com.

Mol Divers ; 23(3): 639-649, 2019 Aug.

Article en En | MEDLINE | ID: mdl-30547372

RESUMEN

A facile, efficient and environmentally safe strategy for the synthesis of pyrazolopyranopyrimidines via one-pot, four-component reaction of hydrazine hydrate, barbituric acid, ethyl acetoacetate, and aromatic aldehydes in polyethylene glycol (PEG) as a safe solvent in the absence of catalyst at ambient temperature has been described. The advantages of the present protocol, such as simplicity, mild conditions, high yields of products, straightforward workup procedure, a green and biodegradable reaction medium, make this new process an attractive to current methodologies.

Asunto(s)

Polietilenglicoles/química; Pirimidinas/química; Pirimidinas/síntesis química; Temperatura; Técnicas de Química Sintética; Tecnología Química Verde

Palabras clave

Catalyst-free; Green synthesis; Multicomponent reaction; One-pot synthesis; Polyethylene glycol (PEG-400); Pyrazolopyranopyrimidines

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Pirimidinas / Temperatura Idioma: En Revista: Mol Divers Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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