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Leptin and IGF1 receptors in alpaca (Vicugna pacos) ovaries.
Gallelli, M F; Bianchi, C; Lombardo, D; Rey, F; Rodriguez, F M; Castillo, V A; Miragaya, M.
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  • Gallelli MF; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina; Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Facultad de Ciencias Veterinarias, UBA, Buenos Aires, Argentina. Electronic address: mgallelli@fvet.uba.ar.
  • Bianchi C; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina; Laboratorio de Endocrinología, Fac. de Veterinaria, UNCPBA, Tandil, Argentina.
  • Lombardo D; Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Facultad de Ciencias Veterinarias, UBA, Buenos Aires, Argentina.
  • Rey F; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina; Laboratorio de Biología Celular y Molecular Aplicada, (ICIVET Litoral, UNL-CONICET), Fac de Cs. Veterinarias, UNL, Santa Fe, Argentina.
  • Rodriguez FM; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina; Laboratorio de Biología Celular y Molecular Aplicada, (ICIVET Litoral, UNL-CONICET), Fac de Cs. Veterinarias, UNL, Santa Fe, Argentina.
  • Castillo VA; Unidad de Endocrinología, Fac. de Cs. Veterinarias, UBA, Buenos Aires, Argentina.
  • Miragaya M; Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Facultad de Ciencias Veterinarias, UBA, Buenos Aires, Argentina.
Anim Reprod Sci ; 200: 96-104, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30545749
Folliculogenesis and ovulation are regulated by gonadotrophins and other factors such as Insulin like growth factor 1 (IGF1) and leptin. In various species the presence of IGF1 receptor (IGF1R) and leptin receptor (ObR) has been detected in the ovary, but not in the alpaca. Thus, the aim of the present study was to evaluate the presence of these receptors in this tissue and analyze if the presence of these receptors in the ovary is related to the presence of a corpus luteum (CL) and if abundances, as determined by immunostaining intensity vary with follicle size. The IGF1R and ObR were identified in primary and secondary follicles, granulosa and theca interna cells of tertiary follicles and in CL. There were greater abundances of IGF1R in granulosa cells of tertiary follicles of ovaries without compared with those with CL. In both groups, the immunostaining of granulosa cells was greater than in theca interna cells. The abundance of ObR was greater in primary and secondary follicles, and theca interna cells of tertiary follicles in ovaries with than those without CL. Immunostaining of granulosa cells was greater than theca interna cells only in ovaries without CL. There were no differences in the abundance of ObR and IGF1R between primary and secondary follicles and granulosa cells of tertiary follicles, neither in ovaries with or without CL. The abundance of IGF1R was not correlated with abundance of ObR neither in ovaries with or without CL. These results indicate a possible role for IGF and leptin in ovarian function. Furthermore, these receptors could be regulated by ovarian steroid hormones because abundance of these receptors in ovaries varies depending on whether there is a CL present in the ovary.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Camélidos del Nuevo Mundo / Receptor IGF Tipo 1 / Receptores de Leptina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anim Reprod Sci Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Camélidos del Nuevo Mundo / Receptor IGF Tipo 1 / Receptores de Leptina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anim Reprod Sci Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos