Targeting IL-13R&#945;2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models.

Mrowczynski, Oliver D; Payne, Russell A; Bourcier, Alexandre J; Mau, Christine Y; Slagle-Webb, Becky; Shenoy, Ganesh; Madhankumar, Achuthamangalam B; Abramson, Stephan B; Wolfe, Darren; Harbaugh, Kimberly S; Rizk, Elias B; Connor, James R

Targeting IL-13Rα2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models.

Mrowczynski, Oliver D; Payne, Russell A; Bourcier, Alexandre J; Mau, Christine Y; Slagle-Webb, Becky; Shenoy, Ganesh; Madhankumar, Achuthamangalam B; Abramson, Stephan B; Wolfe, Darren; Harbaugh, Kimberly S; Rizk, Elias B; Connor, James R.

Afiliación

Mrowczynski OD; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Payne RA; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Bourcier AJ; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Mau CY; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Slagle-Webb B; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Shenoy G; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Madhankumar AB; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Abramson SB; 2Targepeutics, Inc., Hershey, Pennsylvania; and.
Wolfe D; 3LifeSci Partners, LLC, Vancouver, Washington.
Harbaugh KS; 2Targepeutics, Inc., Hershey, Pennsylvania; and.
Rizk EB; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.
Connor JR; 1Penn State University Department of Neurosurgery, Milton S. Hershey Medical Center.

J Neurosurg ; : 1-11, 2018 Nov 01.

Article en En | MEDLINE | ID: mdl-30544352

Palabras clave

ALT = alanine transaminase; AST = aspartate transaminase; BUN = blood urea nitrogen; DMEM = Dulbecco's modified Eagle medium; FBS = fetal bovine serum; H & E = hematoxylin and eosin; IL-13 = interleukin-13; IL-13Rα2 = IL-13 receptor alpha 2; MPNST; MPNST = malignant peripheral nerve sheath tumor; NF1 = neurofibromatosis type 1; PBS = phosphate-buffered saline; Pseudomonas toxin; TCGA = The Cancer Genome Atlas; hIL-13 = human IL-13; interleukin-13 receptor alpha 2; intratumoral treatment; murine model; oncology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Neurosurg Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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