Your browser doesn't support javascript.
loading
Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.
Nautiyal, Manisha; Shaltout, Hossam A; Chappell, Mark C; Diz, Debra I.
Afiliación
  • Nautiyal M; Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC.
  • Shaltout HA; Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC.
  • Chappell MC; Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Winston-Salem, NC.
  • Diz DI; General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
J Cardiovasc Pharmacol ; 73(3): 143-148, 2019 03.
Article en En | MEDLINE | ID: mdl-30540685
Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), whereas AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension. To examine effects of a putative preferential mitochondrial ROS scavenger in the brain of (mRen2)27 rats, ICV infusions of Mito-TEMPO (3.2 µg/2.5 µL/h) were compared with artificial cerebrospinal fluid (aCSF; 2.5 µL/h) and combination AT1 receptor antagonist candesartan (CAN: 4 µg/2.5 µL/h) plus Ang-(1-7) (0.1 µg/2.5 µL/h) treatment. MAP was lower after CAN + Ang-(1-7) treatment, and both vagal and sympathetic components of BRS and sympathovagal balance were improved. By contrast, Mito-TEMPO improved sympathetic components of BRS and tended to improve overall sympathovagal balance but failed to alter MAP in this model of hypertension. Although further studies are required to determine whether Mito-TEMPO or CAN + Ang-(1-7) treatment at the doses used altered mitochondrial ROS, optimal therapeutic benefits are achieved by shifting the balance from Ang II toward Ang-(1-7) in this model of chronic RAS-dependent hypertension.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Fragmentos de Péptidos / Piperidinas / Sistema Nervioso Simpático / Tetrazoles / Nervio Vago / Bencimidazoles / Angiotensina I / Depuradores de Radicales Libres / Renina Límite: Animals Idioma: En Revista: J Cardiovasc Pharmacol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Fragmentos de Péptidos / Piperidinas / Sistema Nervioso Simpático / Tetrazoles / Nervio Vago / Bencimidazoles / Angiotensina I / Depuradores de Radicales Libres / Renina Límite: Animals Idioma: En Revista: J Cardiovasc Pharmacol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos