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Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas.
Yi, Xiaoping; Guan, Xiao; Zhang, Youming; Liu, Longfei; Long, Xueying; Yin, Hongling; Wang, Zhongjie; Li, Xuejun; Liao, Weihua; Chen, Bihong T; Zee, Chishing.
Afiliación
  • Yi X; 1Department of Radiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008 People's Republic of China.
  • Guan X; 2Postdoctoral Research Workstation of Pathology and Pathophysiology, Basic Medical Sciences, Xiangya Hospital, Central South University, Changsha, China.
  • Zhang Y; 3Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
  • Liu L; 1Department of Radiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008 People's Republic of China.
  • Long X; 3Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
  • Yin H; 1Department of Radiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008 People's Republic of China.
  • Wang Z; 4Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
  • Li X; 5Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
  • Liao W; 5Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
  • Chen BT; 1Department of Radiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008 People's Republic of China.
  • Zee C; 6Department of Diagnostic Radiology, City of Hope National Medical Centre, Duarte, CA USA.
EPMA J ; 9(4): 421-429, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30538793
OBJECTIVES: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors. PATIENTS AND METHODS: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Computed tomography (CT) imaging features were evaluated, including long diameter (LD), short diameter (SD), pre-enhanced CT value (CTpre), enhanced CT value (CTpost), shape, homogeneity, necrosis or cystic degeneration (N/C). Radiomic features were extracted and then were used to construct a radiomic signature (Rad-score) and radiomic nomogram. The area under the receiver operating characteristic curve (AUC) was used to evaluate their performance. RESULTS: Sixteen of three hundred forty candidate features were used to build a radiomic signature. The signature was significantly different between the sPHEO and LPA groups (AUC: training, 0.907; validation, 0.902). The radiomic nomogram based on enhanced CT features (M1) consisted of Rad-score, LD, SD, CTpre, shape, homogeneity and N/C (AUC: training, 0.957; validation, 0.967). The pre-enhanced CT features based radiomic nomogram (M2) included Rad-score, LD, SD, CTpre, shape, and homogeneity (AUC: training, 0.955; validation, 0.958). CONCLUSIONS: Our radiomic nomograms based on pre-enhanced and enhanced CT images distinguished sPHEO from LPA. In addition, the promising result using pre-enhanced CT images for predictive diagnostics is important because patients could avoid the additional radiation and risk associated with enhanced CT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: EPMA J Año: 2018 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: EPMA J Año: 2018 Tipo del documento: Article Pais de publicación: Suiza