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Targeted urine metabolomics in preterm neonates with intraventricular hemorrhage.
Sarafidis, K; Begou, O; Deda, O; Gika, H; Agakidis, C; Efstathiou, N; Theodoridis, G.
Afiliación
  • Sarafidis K; 1(st) Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, Kostantinoupoleos 49, 54642 Thessaloniki, Greece. Electronic address: saraf@med.auth.gr.
  • Begou O; Laboratory of Analytical Chemistry, School of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
  • Deda O; Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
  • Gika H; Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
  • Agakidis C; 1(st) Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, Kostantinoupoleos 49, 54642 Thessaloniki, Greece.
  • Efstathiou N; 1(st) Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, Kostantinoupoleos 49, 54642 Thessaloniki, Greece.
  • Theodoridis G; Laboratory of Analytical Chemistry, School of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
J Chromatogr B Analyt Technol Biomed Life Sci ; 1104: 240-248, 2019 Jan 01.
Article en En | MEDLINE | ID: mdl-30530117
Intraventricular hemorrhage (IVH) is a major cause of morbidity and mortality in preterm neonates. Elucidation of the mechanisms underlying IVH and/or development of disease biomarkers is essential. The aim of the study was to investigate the urine metabolic profile of preterm neonates (gestational age < 32 weeks) IVH and explore the role of metabolomics in understanding pathophysiological mechanisms of the disease from which novel biomarkers could be derived. In this single-center, prospective, case-control study, urine samples were collected from seven preterm infants with early IVH (IVH group) and from 11 preterm ones without IVH (control group) on days 1, 3 and 9 of life. Urine metabolites were evaluated using targeted liquid chromatography-tandem mass spectrometry. Demographic and perinatal-clinical characteristics were recorded. Univariate and multivariate statistical analyses were performed. Orthogonal Partial Least Squares-Discriminant Analysis showed that the study groups differed significantly due to alternation in 20 out of the 40 metabolites detected in the urine. Elevated differentiated metabolites included energy intermediates and other important compounds, whereas reduced ones various amino acids, hypoxanthine and nicotinamide. A set of metabolites showed high performance as indicators of IVH, especially during day 1. As evidenced by metabolomics, preterm neonates with IVH demonstrate significant metabolism perturbations. Potentially, a selected panel of metabolites could be used as urine biomarkers of IVH development and/or progression in high-risk preterm infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral / Metaboloma / Metabolómica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral / Metaboloma / Metabolómica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos