Leptin levels predict the development of insulin resistance in a sample of adult men-The Olivetti Heart Study.

D'Elia, L; Strazzullo, P; Iacone, R; Russo, O; Galletti, F

D'Elia, L; Strazzullo, P; Iacone, R; Russo, O; Galletti, F.

Afiliación

D'Elia L; Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Naples, Italy.
Strazzullo P; Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Naples, Italy.
Iacone R; Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Naples, Italy.
Russo O; Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Naples, Italy.
Galletti F; Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Naples, Italy. Electronic address: galletti@unina.it.

Nutr Metab Cardiovasc Dis ; 29(1): 39-44, 2019 01.

Article en En | MEDLINE | ID: mdl-30527422

RESUMEN

BACKGROUND AND AIMS: Leptin (LPT) is associated with unfavourable cardio-metabolic risk profile. Although a number of studies have found a positive association between LPT and insulin resistance (IR), no observational study has evaluated a prospective association to detect a predictive role of LPT in IR. Therefore, the aim of this study was to estimate the role of LPT on the incidence of IR in an 8-year follow-up of a sample of adult men (The Olivetti Heart Study). METHODS AND RESULTS: The study included 527 not diabetic men without IR (homeostasis model assessment - HOMA index < 2.77 UI) at baseline. Baseline LPT was significantly and positively associated with HOMA index, body mass index (BMI), waist circumference and blood pressure. At the end of the 8-year follow-up period, a positive and significant association was detected between baseline LPT and changes in HOMA index (r = 0.25, p < 0.01) and incidence of IR (OR: 2.6, 95%CI: 1.9-3.4). This trend was also confirmed after adjustment for potential confounders. In addition, the predictive value of LPT was found in subjects who had not experienced any weight increase over the years, and for normal weight and excess body weight participants, separately. CONCLUSIONS: The results of this prospective study suggest a predictive role of circulating LPT levels on a reduction of insulin sensitivity over time, independently of main potential confounders, in non-diabetic men without IR at baseline. In addition, in normal weight individuals, LPT levels were associated with development of IR.

Asunto(s)

Trastornos del Metabolismo de la Glucosa/sangre; Trastornos del Metabolismo de la Glucosa/epidemiología; Resistencia a la Insulina; Leptina/sangre; Adulto; Anciano; Biomarcadores/sangre; Estudios de Seguimiento; Trastornos del Metabolismo de la Glucosa/diagnóstico; Humanos; Incidencia; Italia/epidemiología; Masculino; Persona de Mediana Edad; Pronóstico; Estudios Prospectivos; Factores de Riesgo; Factores de Tiempo

Palabras clave

Adipocytokines; Adipokines; HOMA index; Insulin resistance; Leptin

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Leptina / Trastornos del Metabolismo de la Glucosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google