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Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017.
Rahman, Md Mujibur; Been Sayed, Sk Jakaria; Moniruzzaman, Md; Kabir, A K M Humayon; Mallik, Md Uzzwal; Hasan, Md Rockyb; Siddique, Abu Bakar; Hossain, Md Arman; Uddin, Nazim; Hassan, Md Mehedi; Chowdhury, Fazle Rabbi.
Afiliación
  • Rahman MM; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Been Sayed SJ; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Moniruzzaman M; Director General of Health Services, Dhaka, Bangladesh.
  • Kabir AKMH; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Mallik MU; Director General of Health Services, Dhaka, Bangladesh.
  • Hasan MR; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Siddique AB; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Hossain MA; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Uddin N; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Hassan MM; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Chowdhury FR; Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
Am J Trop Med Hyg ; 100(2): 405-410, 2019 02.
Article en En | MEDLINE | ID: mdl-30526743
From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. The median age of the patients at presentation was 38 years (IQR 30-50) with a male (57.3%) predominance. Hypertension and diabetes were the most common comorbidities. The mean (±SD) duration of fever was 3.7 (±1.4) days. Other common manifestations were arthralgia (99.2%), maculopapular rash (50.2%), morning stiffness (49.7%), joint swelling (48.5%), and headache (37.6%). Cases were confirmed by anti-chikungunya IgG (173; 43.3%), IgM (165; 42.3%), and reverse transcription polymerase chain reaction (44; 11.0%). Important laboratory findings include high erythrocyte sedimentation rate (156; 22.6%), raised serum glutamic pyruvic transaminase (73; 10.5%), random blood sugar (54; 7.8%), leukopenia (72; 10.4%), thrombocytopenia (41; 5.9%), and others. The oligo-articular (453; 66.1%) variety of joint involvement was significantly more common compared with the poly-articular (237; 34.5%) variety. Commonly involved joints were the wrist (371; 54.1%), small joints of the hand (321; 46.8%), ankle (251; 36.6%), knee (240; 35.0%), and elbow (228; 33.2%). Eleven cases were found to be complicated with neurological involvement and two of them died. Another patient died due to myocarditis. Public health experts, clinicians, and policymakers could use the results of this study to construct the future strategy tackling chikungunya in Bangladesh and other epidemic countries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Chikungunya / Brotes de Enfermedades / Fiebre Chikungunya / Anticuerpos Antivirales Tipo de estudio: Observational_studies País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2019 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Chikungunya / Brotes de Enfermedades / Fiebre Chikungunya / Anticuerpos Antivirales Tipo de estudio: Observational_studies País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2019 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Estados Unidos