Your browser doesn't support javascript.
loading
Pancreatic Acinar Metaplasia in Distal Esophageal Biopsies Is Associated With Chronic Nonsteroidal Anti-inflammatory Drug Use.
Al Salihi, Suhair; Jaitly, Vanya; Saulino, David M; DuPont, Andrew W; Ertan, Atilla; Everett, Jamie M; Younes, Mamoun.
Afiliación
  • Al Salihi S; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • Jaitly V; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • Saulino DM; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • DuPont AW; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • Ertan A; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • Everett JM; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
  • Younes M; From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and M
Arch Pathol Lab Med ; 143(4): 510-512, 2019 04.
Article en En | MEDLINE | ID: mdl-30525934
CONTEXT.­: The cause of pancreatic acinar metaplasia (PAM) at the distal esophagus/esophagogastric junction is still controversial. Whereas some authors believe it is congenital, others believe it is acquired because of inflammation of the gastric cardia, and more recently it was proposed to be due to chronic proton pump inhibitor use based on a study in rats. OBJECTIVE.­: To determine whether there is correlation between chronic proton pump inhibitor use and PAM in humans. We also investigated the correlation between several clinical and pathologic factors and PAM. DESIGN.­: Four hundred forty-four consecutive biopsies from the distal esophagus/esophagogastric junction were reviewed for the presence of PAM, which was then correlated with several clinical and pathologic findings. RESULTS.­: Pancreatic acinar metaplasia was found in 71 patients (16%). Pancreatic acinar metaplasia was significantly associated with patient age younger than 51 years ( P < .001), chronic carditis ( P = .01), and chronic proton pump inhibitor use ( P = .008). Surprisingly, we also found significant association between PAM and chronic nonsteroidal anti-inflammatory drug use ( P < .001). These associations, including that with chronic nonsteroidal anti-inflammatory drug use, remained significant in multivariate analysis. CONCLUSIONS.­: Our findings confirm the previous reports of significant association between PAM and chronic carditis and the findings from animal studies of association with chronic proton pump inhibitor use. The strong association with chronic nonsteroidal anti-inflammatory drug use has not been previously reported and warrants further studies.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Páncreas Exocrino / Unión Esofagogástrica / Esófago / Metaplasia Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Pathol Lab Med Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Páncreas Exocrino / Unión Esofagogástrica / Esófago / Metaplasia Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Pathol Lab Med Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos