Your browser doesn't support javascript.
loading
Valchlor maintenance therapy for patients with mycosis fungoides who received low dose total skin electron beam treatment.
Jennings, Tara; Duffy, Robert; Gochoco, Ashley; Knoblauch, Kelly; Shi, Wenyin; Alpdogan, S Onder; Porcu, Pierluigi; Werner-Wasik, Maria; Sahu, Joya.
Afiliación
  • Jennings T; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Duffy R; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Gochoco A; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Knoblauch K; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Shi W; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Alpdogan SO; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Porcu P; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Werner-Wasik M; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Sahu J; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA. Joyasahumd@gmail.com.
Chin Clin Oncol ; 8(1): 13, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30525753
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma within the general population. Low dose total skin electron beam therapy (TSEBT) and topical nitrogen mustard (Valchlor) are two treatment modalities that have been proven to be efficacious in the treatment of MF. While each have been studied independently in various clinical trials, the use of Valchlor as maintenance therapy after completion of low dose TSEBT is rarely implemented due to the lack of evidence in the literature. The Jefferson multidisciplinary cutaneous lymphoma clinic has found great success with this combination of treatment and it was the goal of the authors to provide further evidence to its efficacy. The authors conducted a retrospective review of eight patients at the Jefferson multidisciplinary cutaneous lymphoma clinic period. In this study, they were initiated on a regimen of Valchlor as a maintenance therapy after completion of low dose TSEBT. The median MSWAT score before low dose TSEBT was found to be 25.25 with a mean of 39.76. A reduction was found in MSWAT score after low dose TSEBT to a median of 7.68 and a mean of 17.31. Median scores for pruritus were decreased from 3.43 before TSEBT to 1.88 after low dose TSEBT and a decreased in quality of life score median from 6.60 to a median of 2.75. Valchlor proved to be a useful maintenance therapy prolonging time to stage increase by 22.7351 months. Overall this study provides further evidence to the efficacy of Valchlor used as a maintenance therapy after completion of low dose TSEBT.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Micosis Fungoide / Mecloretamina Aspecto: Patient_preference Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Chin Clin Oncol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Micosis Fungoide / Mecloretamina Aspecto: Patient_preference Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Chin Clin Oncol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: China