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Maximumins A-D, Rearranged Labdane-Type Diterpenoids with Four Different Carbon Skeletons from Amomum maximum.
Ji, Kai-Long; Fan, Yao-Yue; Ge, Zhan-Peng; Sheng, Li; Xu, You-Kai; Gan, Li-She; Li, Jing-Ya; Yue, Jian-Min.
Afiliación
  • Ji KL; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
  • Fan YY; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
  • Ge ZP; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
  • Sheng L; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
  • Xu YK; Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Menglun 666303 , China.
  • Gan LS; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou 310058 , China.
  • Li JY; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
  • Yue JM; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Zhangjiang Hi-Tech Park, Shanghai 201203 , China.
J Org Chem ; 84(1): 282-288, 2019 01 04.
Article en En | MEDLINE | ID: mdl-30525625
Four highly rearranged labdane-type diterpenoids, maximumins A-D (1-4) possessing different new carbon skeletons, together with a biosynthetically related known analog 5 were isolated from Amomum maximum. The structures of new compounds with absolute configurations were characterized by spectroscopic and computational approaches. The plausible biogenetic pathways for 1-4 were proposed. These compounds showed moderate to weak activities against nuclear factor kappa B (NF-κB).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbono / Amomum / Diterpenos Tipo de estudio: Prognostic_studies Idioma: En Revista: J Org Chem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbono / Amomum / Diterpenos Tipo de estudio: Prognostic_studies Idioma: En Revista: J Org Chem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos