Your browser doesn't support javascript.
loading
Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
Kurisu, Kota; Zheng, Zhen; Kim, Jong Youl; Shi, Jian; Kanoke, Atsushi; Liu, Jialing; Hsieh, Christine L; Yenari, Midori A.
Afiliación
  • Kurisu K; Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Zheng Z; Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Kim JY; Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Shi J; Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Kanoke A; Department of Neurosurgery, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Liu J; Department of Neurosurgery, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Hsieh CL; Department of Medicine, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Yenari MA; Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
J Cereb Blood Flow Metab ; 39(10): 1906-1918, 2019 10.
Article en En | MEDLINE | ID: mdl-30523715
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor that promotes phagocytosis by myeloid cells such as microglia and macrophages. We previously showed that TREM2 deficiency worsened outcomes from experimental stroke and impeded phagocytosis. However, myeloid cells participating in stroke pathology include both brain resident microglia and circulating macrophages. We now clarify whether TREM2 on brain microglia or circulating macrophages contribute to its beneficial role in ischemic stroke by generating bone marrow (BM) chimeric mice. BM chimera mice from TREM2 knockout (KO) or wild type (Wt) mice were used as donor and recipient mice. Mice were subjected to experimental stroke, and neurological function and infarct volume were assessed. Mice with intact TREM2 in brain microglia showed better neurological recovery and reduced infarct volumes, compared with mice lacking microglial TREM2. Myeloid cell activation and numbers of phagocytes were decreased in mice lacking brain TREM2, compared with mice with intact brain TREM2. These results suggest that TREM2 expression is important for post-stroke recovery, and that TREM2 expression on brain resident microglia is more essential to this recovery, than that of circulating macrophages. These findings might suggest a new therapeutic target for cerebrovascular diseases.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Encéfalo / Glicoproteínas de Membrana / Receptores Inmunológicos / Accidente Cerebrovascular Límite: Animals Idioma: En Revista: J Cereb Blood Flow Metab Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Encéfalo / Glicoproteínas de Membrana / Receptores Inmunológicos / Accidente Cerebrovascular Límite: Animals Idioma: En Revista: J Cereb Blood Flow Metab Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos