Your browser doesn't support javascript.
loading
Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates.
Samart, Nuttaporn; Arhouma, Zeyad; Kumar, Santosh; Murakami, Heide A; Crick, Dean C; Crans, Debbie C.
Afiliación
  • Samart N; Department of Chemistry, Colorado State University, Fort Collins, CO, United States.
  • Arhouma Z; Department of Chemistry, Rajabhat Rajanagarindra University, Chachoengsao, Thailand.
  • Kumar S; Department of Chemistry, Colorado State University, Fort Collins, CO, United States.
  • Murakami HA; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO, United States.
  • Crick DC; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.
  • Crans DC; Department of Chemistry, Colorado State University, Fort Collins, CO, United States.
Front Chem ; 6: 519, 2018.
Article en En | MEDLINE | ID: mdl-30515375
51V NMR spectroscopy is used to document, using speciation analysis, that one oxometalate is a more potent growth inhibitor of two Mycobacterial strains than other oxovanadates, thus demonstrating selectivity in its interaction with cells. Historically, oxometalates have had many applications in biological and medical studies, including study of the phase-problem in X-ray crystallography of the ribosome. The effect of different vanadate salts on the growth of Mycobacterium smegmatis (M. smeg) and Mycobacterium tuberculosis (M. tb) was investigated, and speciation was found to be critical for the observed growth inhibition. Specifically, the large orange-colored sodium decavanadate (V10 O 28 6 - ) anion was found to be a stronger inhibitor of growth of two mycobacterial species than the colorless oxovanadate prepared from sodium metavanadate. The vanadium(V) speciation in the growth media and conversion among species under growth conditions was monitored using 51V NMR spectroscopy and speciation calculations. The findings presented in this work is particularly important in considering the many applications of polyoxometalates in biological and medical studies, such as the investigation of the phase-problem in X-ray crystallography for the ribosome. The findings presented in this work investigate the interactions of oxometalates with other biological systems.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza