Effects of sprint interval or combined aerobic and resistance training on myokines in overweight women with type 2 diabetes: A randomized controlled trial.

Banitalebi, Ebrahim; Kazemi, AbdolReza; Faramarzi, Mohammad; Nasiri, Samira; Haghighi, Marjan Mosalman

Banitalebi, Ebrahim; Kazemi, AbdolReza; Faramarzi, Mohammad; Nasiri, Samira; Haghighi, Marjan Mosalman.

Afiliación

Banitalebi E; Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
Kazemi A; Department of Sport Sciences, Valiaaser University, Rafsanjan, Kerman, Iran.
Faramarzi M; Department of Sport Sciences, Shahrekord University, Shahrekord, Iran. Electronic address: md.faramarzi@gmail.com.
Nasiri S; Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
Haghighi MM; Exercise, Health and Performance, Faculty of Health Sciences, University of Sydney, Australia.

Life Sci ; 217: 101-109, 2019 Jan 15.

Article en En | MEDLINE | ID: mdl-30508516

RESUMEN

Our primary aim was to assess the effects of two different training modalities: sprint interval training (SIT) or combined aerobic and resistance training (Aâ¯+â¯R) on circulating myokines related to metabolic profile and adiposity in type 2 diabetes (T2D). Fifty-two overweight women with T2D [55â¯±â¯6â¯yrs., BMI 28.9â¯±â¯4.1â¯kg/m2, HbA1c 9.4â¯±â¯0.82% (79â¯mmol/mol)] were randomized to SIT (nâ¯=â¯17), Aâ¯+â¯R training (nâ¯=â¯17) or control (nâ¯=â¯18) for 10â¯weeks. Myokines, metabolic outcomes, body composition and cardiorespiratory fitness were assessed at baseline and 48 hours after the last training session/control period. Relationships between myokines and other variables were investigated via linear regression models. Completion rate was 81%. There was no effect of either exercise modality on any myokine. Interlukin-15 decreased over time irrespective of group assignment (pâ¯=â¯0.02). Aerobic capacity (pâ¯=â¯0.01), fasting glucose (pâ¯=â¯0.03) and HbA1c (pâ¯=â¯0.006) improved significantly and similarly in both exercise groups compared to controls. Insulin (pâ¯=â¯0.02), weight (pâ¯=â¯0.020, body max index (BMI) (pâ¯=â¯0.01) decreased significantly over time irrespective of group. Changes in myokines were unrelated to changes in body composition or metabolic profile. Neither SIT or Aâ¯+â¯R training altered myokines measured 48â¯h after exercise in T2D, despite improving aerobic capacity and glucose homeostasis relative to controls. Future studies are needed to elucidate the time course and clinical relevance of putative myokine responses to exercise in this and other cohorts.

Asunto(s)

Diabetes Mellitus Tipo 2/sangre; Diabetes Mellitus Tipo 2/terapia; Terapia por Ejercicio/métodos; Entrenamiento de Intervalos de Alta Intensidad/métodos; Sobrepeso/sangre; Sobrepeso/terapia; Entrenamiento de Fuerza/métodos; Proteína 4 Similar a la Angiopoyetina/sangre; Composición Corporal; Diabetes Mellitus Tipo 2/complicaciones; Diabetes Mellitus Tipo 2/metabolismo; Ejercicio Físico; Tolerancia al Ejercicio; Femenino; Factores de Crecimiento de Fibroblastos/sangre; Fibronectinas/sangre; Humanos; Interleucina-15/sangre; Interleucina-6/sangre; Metaboloma; Persona de Mediana Edad; Osteonectina/sangre; Sobrepeso/complicaciones; Sobrepeso/metabolismo

Palabras clave

Combined Aerobic and Resistance Training (Aâ¯+â¯R); Myokines; Short sprint interval training (SIT); Type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Sobrepeso / Terapia por Ejercicio / Entrenamiento de Fuerza / Entrenamiento de Intervalos de Alta Intensidad Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Life Sci Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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