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The Impact of Prior Season Vaccination on Subsequent Influenza Vaccine Effectiveness to Prevent Influenza-related Hospitalizations Over 4 Influenza Seasons in Canada.
Nichols, M K; Andrew, M K; Ye, L; Hatchette, T F; Ambrose, A; Boivin, G; Bowie, W; Dos Santos, G; Elsherif, M; Green, K; Haguinet, F; Katz, K; Leblanc, J; Loeb, M; MacKinnon-Cameron, D; McCarthy, A; McElhaney, J E; McGeer, A; Powis, J; Richardson, D; Semret, M; Sharma, R; Shinde, V; Smyth, D; Trottier, S; Valiquette, L; Webster, D; McNeil, S A.
Afiliación
  • Nichols MK; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Andrew MK; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Ye L; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Hatchette TF; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Ambrose A; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Boivin G; Centre Hospitalier Universitaire de Québec, Québec City, Canada.
  • Bowie W; University of British Columbia, Vancouver, Canada.
  • Dos Santos G; Business and Decision Life Sciences, Bruxelles, Belgium.
  • Elsherif M; Present affiliation: GSK, Wavre, Belgium.
  • Green K; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • Haguinet F; Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Katz K; GlaxoSmithKline (GSK), Wavre, Belgium.
  • Leblanc J; North York General Hospital, Toronto.
  • Loeb M; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • MacKinnon-Cameron D; McMaster University, Hamilton.
  • McCarthy A; Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia.
  • McElhaney JE; The Ottawa Hospital, Sudbury.
  • McGeer A; Health Sciences North Research Institute, Sudbury.
  • Powis J; Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Richardson D; Michael Garron Hospital, Toronto.
  • Semret M; William Osler Health System, Brampton, Ontario.
  • Sharma R; McGill University, Montreal, Québec.
  • Shinde V; GSK, Mississauga, Ontario, Canada.
  • Smyth D; GSK, King of Prussia, Pennsylvania.
  • Trottier S; Present affiliation: Novavax Vaccines, Washington, D.C.
  • Valiquette L; The Moncton Hospital, New Brunswick.
  • Webster D; Centre Hospitalier Universitaire de Québec, Québec City, Canada.
  • McNeil SA; Université de Sherbrooke, Québec.
Clin Infect Dis ; 69(6): 970-979, 2019 08 30.
Article en En | MEDLINE | ID: mdl-30508064
BACKGROUND: Recent studies have demonstrated the possibility of negative associations between prior influenza vaccines and subsequent influenza vaccine effectiveness (VE), depending on season and strain. We investigated this association over 4 consecutive influenza seasons (2011-2012 through 2014-2015) in Canada. METHODS: Using a matched test-negative design, laboratory-confirmed influenza cases and matched test-negative controls admitted to hospitals were enrolled. Patients were stratified into 4 groups according to influenza vaccine history (not vaccinated current and prior season [referent], vaccinated prior season only, vaccinated current season only, and vaccinated both current and prior season). Conditional logistic regression was used to estimate VE; prior vaccine impact was assessed each season for overall effect and effect stratified by age (<65 years, ≥65 years) and type/subtype (A/H1N1, A/H3N2, influenza B). RESULTS: Overall, mainly nonsignificant associations were observed. Trends of nonsignificant decreased VE among patients repeatedly vaccinated in both prior and current season relative to the current season only were observed in the A/H3N2-dominant seasons of 2012-2013 and 2014-2015. Conversely, in 2011-2012, during which B viruses circulated, and in 2013-2014, when A/H1N1 circulated, being vaccinated in both seasons tended to result in a high VE in the current season against the dominant circulating subtype. CONCLUSIONS: Prior vaccine impact on subsequent VE among Canadian inpatients was mainly nonsignificant. Even in circumstances where we observed a trend of negative impact, being repeatedly vaccinated was still more effective than not receiving the current season's vaccine. These findings favor continuation of annual influenza vaccination recommendations, particularly in older adults. CLINICAL TRIALS REGISTRATION: NCT01517191.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estaciones del Año / Vacunas contra la Influenza / Vacunación / Gripe Humana / Hospitalización Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estaciones del Año / Vacunas contra la Influenza / Vacunación / Gripe Humana / Hospitalización Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos