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Temperature Sensing Is Distributed throughout the Regulatory Network that Controls FLC Epigenetic Silencing in Vernalization.
Antoniou-Kourounioti, Rea L; Hepworth, Jo; Heckmann, Amélie; Duncan, Susan; Qüesta, Julia; Rosa, Stefanie; Säll, Torbjörn; Holm, Svante; Dean, Caroline; Howard, Martin.
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  • Antoniou-Kourounioti RL; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Hepworth J; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Heckmann A; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Duncan S; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Qüesta J; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Rosa S; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Säll T; Department of Biology, Lund University, Lund 223 62, Sweden.
  • Holm S; Department of Natural Sciences, Mid Sweden University, Sundsvall 851 70, Sweden.
  • Dean C; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: caroline.dean@jic.ac.uk.
  • Howard M; John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: martin.howard@jic.ac.uk.
Cell Syst ; 7(6): 643-655.e9, 2018 12 26.
Article en En | MEDLINE | ID: mdl-30503646
Many organisms need to respond to complex, noisy environmental signals for developmental decision making. Here, we dissect how Arabidopsis plants integrate widely fluctuating field temperatures over month-long timescales to progressively upregulate VERNALIZATION INSENSITIVE3 (VIN3) and silence FLOWERING LOCUS C (FLC), aligning flowering with spring. We develop a mathematical model for vernalization that operates on multiple timescales-long term (month), short term (day), and current (hour)-and is constrained by experimental data. Our analysis demonstrates that temperature sensing is not localized to specific nodes within the FLC network. Instead, temperature sensing is broadly distributed, with each thermosensory process responding to specific features of the plants' history of exposure to warm and cold. The model accurately predicts FLC silencing in new field data, allowing us to forecast FLC expression in changing climates. We suggest that distributed thermosensing may be a general property of thermoresponsive regulatory networks in complex natural environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Dominio MADS / Proteínas de Arabidopsis / Epigénesis Genética / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Syst Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Dominio MADS / Proteínas de Arabidopsis / Epigénesis Genética / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Syst Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos