Your browser doesn't support javascript.
loading
Development of photoactive Sweet-C60 for pancreatic cancer stellate cell therapy.
Serda, Maciej; Ware, Matthew J; Newton, Jared M; Sachdeva, Sanchit; Krzykawska-Serda, Martyna; Nguyen, Lam; Law, Justin; Anderson, Andrew O; Curley, Steven A; Wilson, Lon J; Corr, Stuart J.
Afiliación
  • Serda M; Department of Chemistry & Smalley-Curl Institute, Rice University, Houston, TX 77251, USA.
  • Ware MJ; Institute of Chemistry, University of Silesia in Katowice, Katowice, 40-006, Poland.
  • Newton JM; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Sachdeva S; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Krzykawska-Serda M; Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Nguyen L; Interdepartmental Graduate Program in Translational Biology & Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
  • Law J; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Anderson AO; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Curley SA; Faculty of Biochemistry, Biophysics & Biotechnology, Jagiellonian University, Kraków, 30-387, Poland.
  • Wilson LJ; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Corr SJ; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Nanomedicine (Lond) ; 13(23): 2981-2993, 2018 12.
Article en En | MEDLINE | ID: mdl-30501557
AIM: Glycoconjugated C60 derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the case of pancreatic adenocarcinoma and its dense stroma, which is known to be driven by a subset of pancreatic stellate cells. MATERIALS & METHODS: Herein, we describe the synthesis and biological characterization of a hexakis-glucosamine C60 derivative (termed 'Sweet-C60'). RESULTS: Synthesized fullerene derivative predominantly accumulates in the nucleus of pancreatic stellate cells; is inherently nontoxic up to concentrations of 1 mg/ml; and is photoactive when illuminated with blue and green light, allowing its use as a photodynamic therapy agent. CONCLUSION: Obtained glycoconjugated nanoplatform is a promising nanotherapeutic for pancreatic cancer.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Glicoconjugados / Fármacos Fotosensibilizantes / Fulerenos / Células Estrelladas Pancreáticas Límite: Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Glicoconjugados / Fármacos Fotosensibilizantes / Fulerenos / Células Estrelladas Pancreáticas Límite: Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido