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Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area.
Brito, Bruno Oliveira de Figueiredo; Pinto-Filho, Marcelo Martins; Cardoso, Clareci Silva; Di Lorenzo Oliveira, Claudia; Ferreira, Ariela Mota; de Oliveira, Lea Campos; Gomes, Paulo; Nunes, Maria do Carmo Pereira; Sabino, Ester Cerdeira; Ribeiro, Antonio Luiz Pinho.
Afiliación
  • Brito BOF; Programa de Pós-graduação Infectologia e Medicina Tropical, Faculdade de Medicina da Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
  • Pinto-Filho MM; Programa de Pós-graduação Infectologia e Medicina Tropical, Faculdade de Medicina da Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
  • Cardoso CS; Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil.
  • Di Lorenzo Oliveira C; Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil.
  • Ferreira AM; State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
  • de Oliveira LC; Department of Infectious Diseases, School of Medicine and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
  • Gomes P; Centro de Telessaúde do Hospital das Clínicas da Universidade Federal de Minas Gerais, Brazil.
  • Nunes MDCP; Programa de Pós-graduação Infectologia e Medicina Tropical, Faculdade de Medicina da Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
  • Sabino EC; Department of Infectious Diseases, School of Medicine and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
  • Ribeiro ALP; Programa de Pós-graduação Infectologia e Medicina Tropical, Faculdade de Medicina da Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Centro de Telessaúde do Hospital das Clínicas da Universidade Federal de Minas Gerais, Brazil. Electronic address: tom@hc.ufmg.br.
J Electrocardiol ; 51(6): 1039-1043, 2018.
Article en En | MEDLINE | ID: mdl-30497727
Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62-14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33-11.67); 16.04 (CI 95% 9.27-27.77) and 47.82 (CI 95% 17.98-127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Cardiomiopatía Chagásica / Péptido Natriurético Encefálico / Electrocardiografía Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Electrocardiol Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Cardiomiopatía Chagásica / Péptido Natriurético Encefálico / Electrocardiografía Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Electrocardiol Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos