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Zebrafish models of diabetes-related CNS pathogenesis.
Lakstygal, Anton M; de Abreu, Murilo S; Lifanov, Dmitry A; Wappler-Guzzetta, Edina A; Serikuly, Nazar; Alpsyshov, Erik T; Wang, DongMei; Wang, MengYao; Tang, ZhiChong; Yan, DongNi; Demin, Konstantin A; Volgin, Andrey D; Amstislavskaya, Tamara G; Wang, JiaJia; Song, Cai; Alekseeva, Polina; Kalueff, Allan V.
Afiliación
  • Lakstygal AM; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
  • Lifanov DA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; School of Pharmacy, Southwes
  • Wappler-Guzzetta EA; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
  • Serikuly N; School of Pharmacy, Southwest University, Chongqing, China.
  • Alpsyshov ET; School of Pharmacy, Southwest University, Chongqing, China.
  • Wang D; School of Pharmacy, Southwest University, Chongqing, China.
  • Wang M; School of Pharmacy, Southwest University, Chongqing, China.
  • Tang Z; School of Pharmacy, Southwest University, Chongqing, China.
  • Yan D; School of Pharmacy, Southwest University, Chongqing, China.
  • Demin KA; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
  • Volgin AD; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
  • Amstislavskaya TG; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
  • Wang J; Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China.
  • Song C; Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China.
  • Alekseeva P; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
  • Kalueff AV; School of Pharmacy, Southwest University, Chongqing, China; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg
Prog Neuropsychopharmacol Biol Psychiatry ; 92: 48-58, 2019 06 08.
Article en En | MEDLINE | ID: mdl-30476525
Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Enfermedades del Sistema Nervioso Central / Diabetes Mellitus / Modelos Animales de Enfermedad Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Enfermedades del Sistema Nervioso Central / Diabetes Mellitus / Modelos Animales de Enfermedad Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido