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Paraquat exposure and Parkinson's disease: A systematic review and meta-analysis.
Tangamornsuksan, Wimonchat; Lohitnavy, Ornrat; Sruamsiri, Rosarin; Chaiyakunapruk, Nathorn; Norman Scholfield, C; Reisfeld, Brad; Lohitnavy, Manupat.
Afiliación
  • Tangamornsuksan W; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Lohitnavy O; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Sruamsiri R; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Chaiyakunapruk N; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Norman Scholfield C; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Reisfeld B; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
  • Lohitnavy M; Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
Arch Environ Occup Health ; 74(5): 225-238, 2019.
Article en En | MEDLINE | ID: mdl-30474499
To reconcile and unify available results regarding paraquat exposure and Parkinson's disease (PD), we conducted a systematic review and meta-analysis to provide a quantitative estimate of the risk of PD associated with paraquat exposure. Six scientific databases including PubMed, Cochrane libraries, EMBASE, Scopus, ISI Web of Knowledge, and TOXLINE were systematically searched. The overall odds ratios (ORs) with corresponding 95% CIs were calculated using a random-effects model. Of 7,309 articles identified, 13 case control studies with 3,231 patients and 4,901 controls were included into our analysis. Whereas, one prospective cohort studies was included into our systematic review. A subsequent meta-analysis showed an association between PD and paraquat exposure (odds ratio = 1.64 (95% CI: 1.27-2.13; I2 = 24.8%). There is a statistically significant association between paraquat exposure and PD. Thus, future studies regarding paraquat and Parkinson's disease are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraquat / Enfermedad de Parkinson / Exposición a Riesgos Ambientales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Environ Occup Health Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paraquat / Enfermedad de Parkinson / Exposición a Riesgos Ambientales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Environ Occup Health Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2019 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos