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Super Giant Growth Hormone-Secreting Pituitary Adenoma in Young Woman: From Ventricles to Nose.
Penner, Federica; Prencipe, Nunzia; Pennacchietti, Valentina; Pacca, Paolo; Cambria, Valeria; Garbossa, Diego; Zenga, Francesco.
Afiliación
  • Penner F; Section of Neurosurgery, Division of Neuroscience, University of Turin, Turin, Italy. Electronic address: federica.penner@gmail.com.
  • Prencipe N; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.
  • Pennacchietti V; Section of Neurosurgery, Division of Neuroscience, University of Turin, Turin, Italy.
  • Pacca P; Section of Neurosurgery, Division of Neuroscience, University of Turin, Turin, Italy.
  • Cambria V; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.
  • Garbossa D; Section of Neurosurgery, Division of Neuroscience, University of Turin, Turin, Italy.
  • Zenga F; Section of Neurosurgery, Division of Neuroscience, University of Turin, Turin, Italy.
World Neurosurg ; 122: 544-548, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30472284
BACKGROUND: Giant pituitary adenomas are rare tumors that can have a devastating impact on a patient's life. They require a well-studied therapeutic approach that often combines different strategies. CASE DESCRIPTION: A 29-year-old woman was diagnosed with the largest GH-secreting pituitary adenoma reported in the literature, to the best of the author's knowledge. The tumor was removed with a combined approach: endoscopic endonasal transsphenoidal and transcortical transventricular. All available acromegaly drugs were used. After 2 surgeries, a large part of the tumor was removed. Both postoperative courses were uneventful. Because the disease was still active, medical therapy was initiated. The combination of pasireotide, pegvisomant, and cabergoline permitted satisfactory control of hormonal levels. CONCLUSIONS: Giant adenomas, >4 cm, are rare pituitary tumors. Therefore in order to achieve the best clinical results, they require complex management that involves a multidisciplinary team of ear, nose, and throat surgeons; endocrinologists; radiation therapists; ophthalmologists; and neurosurgeons.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenoma / Procedimientos Neuroquirúrgicos / Adenoma Hipofisario Secretor de Hormona del Crecimiento Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenoma / Procedimientos Neuroquirúrgicos / Adenoma Hipofisario Secretor de Hormona del Crecimiento Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos