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Plasma levels of miR-29b and miR-200b in type 2 diabetic retinopathy.
Dantas da Costa E Silva, Maria Enoia; Polina, Evelise Regina; Crispim, Daisy; Sbruzzi, Renan Cesar; Lavinsky, Daniel; Mallmann, Felipe; Martinelli, Nidiane Carla; Canani, Luis Henrique; Dos Santos, Katia Gonçalves.
Afiliación
  • Dantas da Costa E Silva ME; Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Polina ER; Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Crispim D; Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
  • Sbruzzi RC; Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Lavinsky D; Department of Ophthalmology and Otorhinolaryngology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Mallmann F; Ophthalmology Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
  • Martinelli NC; Department of Biology - Sussman Lab, San Diego State University, San Diego, California.
  • Canani LH; Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
  • Dos Santos KG; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
J Cell Mol Med ; 23(2): 1280-1287, 2019 02.
Article en En | MEDLINE | ID: mdl-30467971
MicroRNAs (miRNAs/miRs) are involved in the pathogenesis of diabetes mellitus and its chronic complications, and their circulating levels have emerged as potential biomarkers for the development and progression of diabetes. However, few studies have examined the expression of miRNAs in diabetic retinopathy (DR) in humans. This case-control study aimed to investigate whether the plasma levels of miR-29b and miR-200b are associated with DR in 186 South Brazilians with type 2 diabetes (91 without DR, 46 with non-proliferative DR and 49 with proliferative DR). We also included 20 healthy blood donors to determine the miRNA expression in the general population. Plasma levels of miR-29b and miR-200b were quantified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Proliferative DR was inversely associated with plasma levels of miR-29b (unadjusted OR = 0.694, 95% CI: 0.535-0.900, P = 0.006) and miR-200b (unadjusted OR = 0.797, 95% CI: 0.637-0.997, P = 0.047). However, these associations were lost after controlling for demographic and clinical covariates. In addition, patients with type 2 diabetes had lower miR-200b levels than blood donors. Our findings reinforce the importance of addressing the role of circulating miRNAs, including miR-29 and miR-200b, in DR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / MicroARNs / Diabetes Mellitus Tipo 2 / Retinopatía Diabética Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / MicroARNs / Diabetes Mellitus Tipo 2 / Retinopatía Diabética Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido