Chiral ß-HgS quantum dots: Aqueous synthesis, optical properties and cytocompatibility.
J Colloid Interface Sci
; 537: 422-430, 2019 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-30465977
ß-HgS quantum dots (QDs) have drawn enormous attention due to the size-tunable bandgap and the lowest quantum state in conduction band which have been applied to semiconductor transistor and photodetector. Though ß-HgS is the essential component of Tibetan medicine, the potential toxicity of ß-HgS limits its applications, especially in bio-application. Herein, chiral biomolecule enantiomers N-isobutyryl-L(D)-cysteine (L(D)-NIBC) and L(D)-cysteine (L(D)-Cys) were introduced into HgCl2 and Na2S aqueous solution to synthesize chiral ß-HgS QDs in one-pot, which significantly improved their water-solubility and cytocompatibility. Notably, all chiral ß-HgS QDs showed none cytotoxicity even at high concentration (20â¯mg·L-1), and the cytocompatibility of D-ß-HgS QDs was better than corresponding L-ß-HgS QDs at the concentration of 20â¯mg·L-1. This cytotoxicity discrimination was associated with the chirality inversion of chiral ß-HgS QDs compared with the corresponding chiral ligands. In-situ real-time circular dichroism (CD) monitoring indicated that the chirality of ß-HgS QDs originated from the asymmetrical arrangement of chiral ligands on the achiral core surface. Their chiroptical activity, near-infrared optical absorption (800â¯nm), fluorescence emission (900-1000â¯nm), high-performance photothermal conversion and good cytocompatibility, implied chiral ß-HgS QDs could be used as a candidate material for photothermal therapy or a near-infrared fluorescent probe in organism, which brings a novel insight for bio-application of ß-HgS QDs.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfuros
/
Agua
/
Compuestos de Mercurio
/
Puntos Cuánticos
Límite:
Humans
Idioma:
En
Revista:
J Colloid Interface Sci
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Estados Unidos