Your browser doesn't support javascript.
loading
Low Cholesterol Levels Increase Symptomatic Intracranial Hemorrhage Rates After Intravenous Thrombolysis: A Multicenter Cohort Validation Study.
Lin, Sheng-Feng; Chao, A-Ching; Hu, Han-Hwa; Lin, Ruey-Tay; Chen, Chih-Hung; Chan, Lung; Lin, Huey-Juan; Sun, Yu; Lin, Yung-Yang; Chen, Po-Lin; Lin, Shinn-Kuang; Wei, Cheng-Yu; Lin, Yu-Te; Lee, Jiunn-Tay; Bai, Chyi-Huey.
Afiliación
  • Lin SF; School of Public Health, College of Public Health, Taipei Medical University.
  • Chao AC; Department of Clinical Pathology, Far Eastern Memorial Hospital.
  • Hu HH; Graduate Institute of Clinical Medicine and Department of Neurology, College of Medicine, Kaohsiung Medical University.
  • Lin RT; Department of Neurology, Kaohsiung Medical University Hospital.
  • Chen CH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University.
  • Chan L; Research Center of Cerebrovascular Disease Treatment, College of Medicine, Taipei Medical University.
  • Lin HJ; Department of Neurology, Taipei Medical University-Shaung Ho Hospital.
  • Sun Y; Graduate Institute of Clinical Medicine and Department of Neurology, College of Medicine, Kaohsiung Medical University.
  • Lin YY; Department of Neurology, Kaohsiung Medical University Hospital.
  • Chen PL; Department of Neurology, National Cheng Kung University Hospital.
  • Lin SK; Department of Neurology, National Cheng Kung University.
  • Wei CY; Department of Neurology, Taipei Medical University-Shaung Ho Hospital.
  • Lin YT; Department of Neurology, Chi Mei Medical Center.
  • Lee JT; Department of Neurology, En Chu Kong Hospital.
  • Bai CH; Department of Neurology, Taipei Veterans General Hospital.
J Atheroscler Thromb ; 26(6): 513-527, 2019 Jun 01.
Article en En | MEDLINE | ID: mdl-30464112
AIM: Although a lower level of non-high-density lipoprotein cholesterol (HDL-C) was reported to be inversely associated with spontaneous intracranial hemorrhage (ICH), no enough evidence has verified whether lipid profiles modify hemorrhagic transformation and functional outcomes in patients with acute ischemic treated with thrombolysis. METHODS: This multicenter cohort study included 2373 patients with acute ischemic stroke treated with intravenous thrombolysis between December 2004 and December 2016. Of these, 1845 patients were categorized into either the hyperlipidemia or non-hyperlipidemia group. Symptomatic ICH (SICH) rates within 24-36 h of thrombolytic onset and functional outcomes at 30 and 90 days were longitudinally surveyed. Models of predicting hemorrhagic transformation were used to validate our findings. RESULTS: For enrolled 1845 patients, SICH rates were ≥2-fold reduced for the hyperlipidemia group by the NINDS (adjusted RR: 0.488 [0.281-0.846], p=0.0106), the ECASS II (adjusted RR: 0.318 [0.130-0.776], p=0.0119), and SITS-MOST standards (adjusted RR: 0.214 [0.048-0.957], p=0.0437). The favorable functional rates between the two groups were not significantly different. Lower levels of LDL-C were showed in robust association with SICH. With a cut-off LDL-C value of ＜130 mg/dL, new models are more robust and significant in predicting hemorrhagic transformation within 24-36 h. CONCLUSIONS: This study supports the strong association between reduced LDL-C and increased SICH, but not for functional outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis. LDL-C level of ＜130 mg/dL is supposed to a candidate marker for predicting SICH within 24-36 h.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Terapia Trombolítica / Hemorragias Intracraneales / HDL-Colesterol Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Terapia Trombolítica / Hemorragias Intracraneales / HDL-Colesterol Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Japón