Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After <i>Klebsiella pneumoniae</i> Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival.

Thorenoor, Nithyananda; Umstead, Todd M; Zhang, Xuesheng; Phelps, David S; Floros, Joanna

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival.

Thorenoor, Nithyananda; Umstead, Todd M; Zhang, Xuesheng; Phelps, David S; Floros, Joanna.

Afiliación

Thorenoor N; Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Umstead TM; Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Zhang X; Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Phelps DS; Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Floros J; Center for Host defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, United States.

Front Immunol ; 9: 2404, 2018.

Article en En | MEDLINE | ID: mdl-30459763

Asunto(s)

Predisposición Genética a la Enfermedad; Variación Genética; Interacciones Huésped-Patógeno/genética; Infecciones por Klebsiella/genética; Infecciones por Klebsiella/microbiología; Klebsiella pneumoniae/fisiología; Proteína A Asociada a Surfactante Pulmonar/genética; Animales; Femenino; Infecciones por Klebsiella/tratamiento farmacológico; Infecciones por Klebsiella/mortalidad; Masculino; Ratones; Ratones Noqueados; Ratones Transgénicos; Fagocitos/inmunología; Fagocitos/metabolismo; Pronóstico; Factores Sexuales

Palabras clave

innate host defense; pneumonia infection; pulmonary surfactant protein A; sex differences; surfactant protein A1 and A2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por Klebsiella / Predisposición Genética a la Enfermedad / Proteína A Asociada a Surfactante Pulmonar / Interacciones Huésped-Patógeno / Klebsiella pneumoniae Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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