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Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy.
He, Mei; Wei, Jing-Xiang; Mao, Min; Zhao, Guo-Yan; Tang, Jun-Jie; Feng, Shuang; Lu, Xiu-Min; Wang, Yong-Tang.
Afiliación
  • He M; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
  • Wei JX; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
  • Mao M; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
  • Zhao GY; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
  • Tang JJ; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
  • Feng S; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
  • Lu XM; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
  • Wang YT; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.
Curr Pharm Des ; 24(34): 4051-4059, 2018.
Article en En | MEDLINE | ID: mdl-30457048
The studying of synaptic plasticity, the ability of synaptic connections between neurons to be weakened or strengthened and specifically long-term potentiation (LTP) and long-term depression (LTD), is one of the most active areas of research in neuroscience. The process of synaptic connections playing a crucial role in improving cognitive processes is important to the processing of information in brain. In general, the dysfunction of synaptic plasticity was involved in a wide spectrum of central nervous system (CNS) disorders, including some neurodegenerative disorders. Thus, synaptic plasticity which is a dysfunction reported in neurodegenerative disorders may also be involved in posttraumatic stress disorder (PTSD), an anxiety and/or memory disorder developed after experiencing natural disasters, domestic violence or combat-related trauma. In this review, we mainly focus on discussing the biological function and mechanism for diagnostics and therapy of synaptic plasticity in PTSD and associated comorbidities, such as schizophrenia, depression, sleep disturbances and alcohol dependence, and further studying the molecular mechanisms of PTSD with a particular focus on the LTP/LTD, glutamatergic ligand-receptor systems, voltage-gated calcium channels (VGCCs) and brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB). The summarized function and mechanism of synaptic plasticity in PTSD and its comorbidities may help us further understand PTSD and provide insight into novel neuroplasticity modifying for diagnostics and treatment for PTSD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Plasticidad Neuronal Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Plasticidad Neuronal Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos