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Synthesis of Difluoroalkyl Unsaturated ß-Amino Acid Derivatives Exclusively through Alkyne Difunctionalization.
Wang, Qiang; Jin, Jia-Ni; Chen, Xi; Wang, Xin-Gang; Zhang, Bo-Sheng; Ma, Jun-Wei; Liang, Yong-Min.
Afiliación
  • Wang Q; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Jin JN; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Chen X; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Wang XG; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Zhang BS; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Ma JW; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
  • Liang YM; State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
J Org Chem ; 83(23): 14626-14636, 2018 12 07.
Article en En | MEDLINE | ID: mdl-30451495
Alkynes difunctionalization is a powerful strategy in organic synthesis that provides a convenient synthetic entry for internal alkenes. The main challenge in this field was considered to be the geometry control of the newly formed double bond (thermodynamically controlled or kinetically controlled). Herein, we report a novel procedure (through the cyclic compounds broken) to completely control the regioselectivity of olefins. The products, difluoroalkyl unsaturated ß-amino acid derivatives, have potential applications in some important pharmaceuticals on account of the special nature of fluorine atoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos