Streptolysin O derived from Streptococcus pyogenes inhibits RANKLinduced osteoclastogenesis through the NFκB signaling pathway.
Mol Med Rep
; 19(1): 414-422, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30431141
Streptococcus pyogenes (GAS) is a clinically significant bacterial strain that causes bacterial arthritis, osteomyelitis and implant infections. Infection complications can lead to serious bone destruction. Osteoclasts, the only type of cell with bone resorption function, participate in this process. Streptolysin O (SLO) is produced by almost all clinical Streptococcus pyogenes isolates. However, the role of SLO in bone infection caused by GAS had not been previously examined. The current study was performed to define the effects of SLO on receptor activator of NFκB ligandstimulated osteoclast differentiation in vitro. Results demonstrated that SLO decreased the phosphorylation of p65 and NFκB inhibitor α, suppressed cFOS and nuclear factor of activated Tcells cytoplasmic 1, and downregulated the expression of osteoclast marker genes. SLO also induced apoptosis of mature osteoclasts. The results suggested that SLO blocked osteoclast activation during GAS infection. These findings may prove useful in the development of novel strategies for treating GASassociated bone infectious diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoclastos
/
Osteogénesis
/
Streptococcus pyogenes
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Estreptolisinas
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Transducción de Señal
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FN-kappa B
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Ligando RANK
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Grecia