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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.
Sun, Hao; Piotrowski, David W; Orr, Suvi T M; Warmus, Joseph S; Wolford, Angela C; Coffey, Steven B; Futatsugi, Kentaro; Zhang, Yinsheng; Vaz, Alfin D N.
Afiliación
  • Sun H; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Piotrowski DW; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Orr STM; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Warmus JS; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Wolford AC; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Coffey SB; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Futatsugi K; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Zhang Y; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
  • Vaz ADN; Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America.
PLoS One ; 13(11): e0206279, 2018.
Article en En | MEDLINE | ID: mdl-30427871
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacocinética / Deuterio / Citocromo P-450 CYP3A / Citocromo P-450 CYP2C19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacocinética / Deuterio / Citocromo P-450 CYP3A / Citocromo P-450 CYP2C19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos