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The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter, Susanne; Jumpertz, Thorsten; Hüttenrauch, Melanie; Ogorek, Isabella; Gerber, Hermeto; Storck, Steffen E; Zampar, Silvia; Dimitrov, Mitko; Lehmann, Sandra; Lepka, Klaudia; Berndt, Carsten; Wiltfang, Jens; Becker-Pauly, Christoph; Beher, Dirk; Pietrzik, Claus U; Fraering, Patrick C; Wirths, Oliver; Weggen, Sascha.
Afiliación
  • Walter S; Department of Neuropathology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Jumpertz T; Department of Neuropathology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Hüttenrauch M; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, von-Siebold Strasse 5, 37075, Goettingen, Germany.
  • Ogorek I; Department of Neuropathology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Gerber H; Foundation Eclosion, 1228 Plan-les-Ouates and Campus Biotech Innovation Park, 1202, Geneva, Switzerland.
  • Storck SE; Department of Biology, University of Fribourg, 1700, Fribourg, Switzerland.
  • Zampar S; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany.
  • Dimitrov M; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, von-Siebold Strasse 5, 37075, Goettingen, Germany.
  • Lehmann S; Brain Mind Institute, Swiss Federal Institute of Technology, 1015, Lausanne, Switzerland.
  • Lepka K; Department of Neuropathology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Berndt C; Department of Neurology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Wiltfang J; Department of Neurology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
  • Becker-Pauly C; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, von-Siebold Strasse 5, 37075, Goettingen, Germany.
  • Beher D; Institute of Biochemistry, Christian-Albrechts-University, Otto-Hahn-Platz 9, 24118, Kiel, Germany.
  • Pietrzik CU; Asceneuron SA, EPFL Innovation Park, 1015, Lausanne, Switzerland.
  • Fraering PC; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany.
  • Wirths O; Foundation Eclosion, 1228 Plan-les-Ouates and Campus Biotech Innovation Park, 1202, Geneva, Switzerland.
  • Weggen S; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, von-Siebold Strasse 5, 37075, Goettingen, Germany. owirths@gwdg.de.
Acta Neuropathol ; 137(2): 239-257, 2019 02.
Article en En | MEDLINE | ID: mdl-30426203
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Proteína ADAMTS4 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Proteína ADAMTS4 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania