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Assessment of Bone and Muscle Measurements by Peripheral Quantitative Computed Tomography in Geriatric Patients.
Drey, M; Henkel, M; Petermeise, S; Weiß, S; Ferrari, U; Rottenkolber, M; Schmidmaier, R.
Afiliación
  • Drey M; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany. Electronic address: Michael.Drey@med.uni-muenchen.de.
  • Henkel M; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany.
  • Petermeise S; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany.
  • Weiß S; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany.
  • Ferrari U; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany.
  • Rottenkolber M; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany.
  • Schmidmaier R; Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universität München (LMU), München, Bavaria,Germany; Medizinische Klinik und Poliklinik IV, Schwerpunkt Endokrinologie, Klinikum derUniversität München (LMU), München, Bavaria, Germany.
J Clin Densitom ; 23(4): 604-610, 2020.
Article en En | MEDLINE | ID: mdl-30425007
The loss of bone and muscle mass increases the risk of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) loses sensitivity in older age. The purpose of this study was to evaluate bone and muscle measurements of peripheral quantitative computed tomography (pQCT) in a geriatric cohort with osteoporosis. Bone mineral density and muscle area of 168 patients aged 65 years and older (76.3 ± 6.5) were measured with pQCT at distal forearm additionally to an osteoporosis assessment consisting of anamnesis, blood test and DXA of lumbar spine and hip. Prior fractures were categorized in minor and major osteoporotic fractures. Logistic regression was used to show the association of bone mineral density and muscle area with major fractures. 54.8% of the participants had at least one major fracture. Bone mineral density measured with pQCT and muscle area were significantly associated with these fractures (total and trabecular bone mineral density OR 2.243 and 2.195, p < 0.01; muscle area OR 2.378, p < 0.05), whereas DXA bone mineral density showed no significant association. These associations remained after adjustment for age, sex, BMI, physical activity and other factors. In all models for patients >75 years only muscle area was significantly associated (OR 5.354, p < 0.05) with major fractures. Measurement of bone mineral density and muscle area with pQCT seems to have advantage over DXA in fracture association in geriatric patients. Measuring muscle area also adds useful information to estimate the presence of osteosarcopenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radio (Anatomía) / Músculo Esquelético Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Clin Densitom Asunto de la revista: ORTOPEDIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radio (Anatomía) / Músculo Esquelético Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Clin Densitom Asunto de la revista: ORTOPEDIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos