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Inherited anxiety-related parent-infant dyads alter LHPA activity.
Ullmann, E; Licinio, J; Perry, S W; White, L O; Klein, A M; Barthel, A; Petrowski, K; Stalder, T; Oratovski, B; von Klitzing, K; Bornstein, S R; Kirschbaum, C.
Afiliación
  • Ullmann E; a Department of Medicine , Carl Gustav Carus, Technical University of Dresden , Dresden , Germany.
  • Licinio J; b Department of Child and Adolescent Psychiatry , Psychotherapy, and Psychosomatics, University of Leipzig , Leipzig , Germany.
  • Perry SW; c College of Medicine , SUNY Upstate Medical University , New York , NY, USA.
  • White LO; c College of Medicine , SUNY Upstate Medical University , New York , NY, USA.
  • Klein AM; b Department of Child and Adolescent Psychiatry , Psychotherapy, and Psychosomatics, University of Leipzig , Leipzig , Germany.
  • Barthel A; b Department of Child and Adolescent Psychiatry , Psychotherapy, and Psychosomatics, University of Leipzig , Leipzig , Germany.
  • Petrowski K; d International Psychoanalytic University Berlin , Berlin, Germany.
  • Stalder T; a Department of Medicine , Carl Gustav Carus, Technical University of Dresden , Dresden , Germany.
  • Oratovski B; e Medicover , Bochum , Germany.
  • von Klitzing K; f Department of Psychology , University of Witten/Herdecke , Witten/Herdecke , Germany.
  • Bornstein SR; g Department of Psychology , Biopsychology, Technical University of Dresden , Dresden , Germany.
  • Kirschbaum C; h Department of Developmental Psychology , University of Siegen , Siegen , Germany.
Stress ; 22(1): 27-35, 2019 01.
Article en En | MEDLINE | ID: mdl-30424700
The pathogenesis of post-traumatic stress disorder (PTSD) is incompletely understood. We hypothesize that disruptions in mother-child relations may be a key contributor to development of PTSD. A normal and healthy separation-individuation process requires adaptations of self- and interactive contingency in both the mother and her child, especially in early childhood development. Anxious mothers are prone to overprotection, which may hinder the individuation process in their children. We examined long-term stress hormones and other stress markers in subjects three generations removed from the Holocaust, to assess the long-term consequences of inherited behavioral and physiological responses to prior stress and trauma. Jewish subjects who recalled overprotective parental behavior had higher hairsteroid-concentrations and dampened limbic-hypothalamic-pituitary-adrenal (LHPA) axis reactivity compared to German and Russian-German subjects with overprotective parents. We suggest that altered LHPA axis activity in maternally overprotected Jewish subjects may indicate a transmitted pathomechanism of "frustrated individuation" resulting from cross-generational anti-Semitic experiences. Thus measurements of hairsteroid-concentrations and parenting practices may have clinical value for diagnosis of PTSD. We propose that this apparent inherited adaptivity of LHPA axis activity could promote higher individual stress resistance, albeit with risk of an allostatic overload.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Sistema Hipotálamo-Hipofisario / Relaciones Madre-Hijo Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Sistema Hipotálamo-Hipofisario / Relaciones Madre-Hijo Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido