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Reduced RBM3 expression is associated with aggressive tumor features in esophageal cancer but not significantly linked to patient outcome.
Grupp, Katharina; Hofmann, Bianca; Kutup, Asad; Bachmann, Kai; Bogoevski, Dean; Melling, Nathaniel; Uzunoglu, Faik Guntac; El Gammal, Alexander Tarek; Koop, Christina; Simon, Ronald; Steurer, Stefan; Krech, Till; Burdak-Rothkamm, Susanne; Jacobsen, Frank; Sauter, Guido; Izbicki, Jakob; Wilczak, Waldemar.
Afiliación
  • Grupp K; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.grupp@uke.de.
  • Hofmann B; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.grupp@uke.de.
  • Kutup A; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bachmann K; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bogoevski D; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Melling N; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Uzunoglu FG; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • El Gammal AT; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Koop C; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Simon R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Steurer S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Krech T; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Burdak-Rothkamm S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Jacobsen F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Sauter G; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Izbicki J; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Wilczak W; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
BMC Cancer ; 18(1): 1106, 2018 Nov 12.
Article en En | MEDLINE | ID: mdl-30419865
BACKGROUND: RBM3 expression has been suggested as prognostic marker in several cancer types. The purpose of this study was to assess the prevalence and clinical significance of altered RBM3 expression in esophageal cancer. METHODS: RBM3 protein expression was measured by immunohistochemistry using tissue microarrays containing samples from 359 esophageal adenocarcinoma (EAC) and 254 esophageal squamous cell cancer (ESCC) patients with oncological follow-up data. RESULTS: While nuclear RBM3 expression was always high in benign esophageal epithelium, high RBM3 expression was only detectable in 66.4% of interpretable EACs and 59.3% of ESCCs. Decreased RBM3 expression was linked to a subset of EACs with advanced UICC stage and presence of distant metastasis (P = 0.0031 and P = 0.0024). In ESCC, decreased RBM3 expression was associated with advanced UICC stage, high tumor stage, and positive lymph node status (P = 0.0213, P = 0.0061, and P = 0.0192). However, RBM3 expression was largely unrelated to survival of patients with esophageal cancer (EAC: P = 0.212 and ESCC: P = 0.5992). CONCLUSIONS: In summary, the present study shows that decreased RBM3 expression is associated with unfavourable esophageal cancer phenotype, but not significantly linked to patient prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteínas de Unión al ARN Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteínas de Unión al ARN Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido